Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Column Efficiency: Plate Theory01:10

Column Efficiency: Plate Theory

2.1K
Band broadening in a chromatography column is measured by its efficiency. This is determined by the number of theoretical plates (N). Theoretical plate theory states that a separation column consists of a continuous series of imaginary plates where solute equilibration occurs between stationary and mobile phases.
A higher number of theoretical plates signifies better column efficiency and improved separation capabilities. Plate height affects bandwidth and separation quality; it is inversely...
2.1K
Electric Field of Parallel Conducting Plates01:16

Electric Field of Parallel Conducting Plates

1.8K
Gauss' law relates the electric flux through a closed surface to the net charge enclosed by that surface. Gauss's law can be applied to find the electric field and the charge enclosed in a region depending on its charge distribution.
Consider a cross-section of a thin, infinite conducting plate having a positive charge. For such a large thin plate, as the thickness of the plate tends to zero, the positive charges lie on the plate's two large faces. Without an external electric field, the...
1.8K
Fluid Pressure over Curved Plate of Constant Width01:12

Fluid Pressure over Curved Plate of Constant Width

2.0K
When a curved plate of constant width is submerged in a liquid, the pressure acting normal to the plate varies continuously both in magnitude and direction. Calculating the magnitude and location of the resultant force at a point is often challenging for such cases. One of the methods to determine the resultant force and its location involves separately calculating the horizontal and vertical components of the resultant force. This complex calculation can be simplified by representing the...
2.0K
Steady, Laminar Flow Between Parallel Plates01:17

Steady, Laminar Flow Between Parallel Plates

892
Understanding steady, laminar flow between parallel plates is essential for analyzing and designing flow in narrow rectangular channels, commonly found in various water conveyance and drainage systems. The Navier-Stokes equations govern fluid motion and are generally challenging to solve due to their nonlinearity. However, simplifications are possible in certain cases, like the steady laminar flow between parallel plates. For this scenario, we assume steady, incompressible, laminar flow.
892
Fluid Pressure over Flat Plate of Constant Width01:05

Fluid Pressure over Flat Plate of Constant Width

2.5K
When a body is submerged in water, it experiences fluid pressure acting normal on its surface and distributed over its area. For better design structures, it is crucial to determine the magnitude and location of the resultant force acting on the surface. In the case of a rectangular plate of constant width submerged in water, the pressure increases with depth, resulting in a linearly varying trapezoidal pressure distribution from the upper to the lower edge of the plate.
The resultant force...
2.5K
Fluid Pressure over Flat Plate of Variable Width01:02

Fluid Pressure over Flat Plate of Variable Width

2.1K
When a flat plate is submerged in a fluid, the fluid exerts pressure on the plate. This pressure can lead to many different phenomena, including drag and buoyancy. To understand the behavior of the fluid over a flat plate of variable width, it is essential to analyze the distribution of the pressure exerted.
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Platelet TREM-Like Transcript-1 (TLT-1) regulation in healthy donors and patients at risk of bleeding and thrombosis.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Discovery of a sulfotyrosine-motif in the human TrkB extracellular domain required for agonist activation.

bioRxiv : the preprint server for biology·2026
Same author

Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype.

PLoS pathogens·2025
Same author

Platelet mitochondrial transfer via extracellular vesicles modulates neutrophil phenotype and function.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Thrombocytopenia in critically ill trauma patients is associated with the pattern and duration of postinjury organ dysfunction.

Research and practice in thrombosis and haemostasis·2025
Same author

Platelets and inflammation-insights from platelet non-coding RNA content and release in the Bruneck study and the PACMAN-AMI trial.

Cardiovascular research·2025
Same journal

Hexokinase controls platelet activation and hemostasis.

Platelets·2026
Same journal

Chemiluminescence resonance energy transfer-based method to investigate the platelet surface molecule in acute myocardial infarction.

Platelets·2026
Same journal

Nanobodies to GPVI as alternative reagents for platelet spreading.

Platelets·2026
Same journal

Neural network reveals platelet age from fluorescence microscopy images.

Platelets·2026
Same journal

Sixty years of research into ancestry differences in platelet function.

Platelets·2026
Same journal

Platelet-rich plasma concentrations regulate MSCs osteogenesis via MAPK/PI3K-AKT pathways to mitigate inflammatory bone loss.

Platelets·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

32.3K

96-well plate-based aggregometry.

Melissa V Chan1, Paul C Armstrong1, Timothy D Warner1

  • 1a Centre for Immunobiology , The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , UK.

Platelets
|March 16, 2018
PubMed
Summary
This summary is machine-generated.

A novel 96-well plate aggregometry method offers a standardized, cost-effective alternative to traditional light transmission aggregometry (LTA) for assessing platelet function in research and clinical settings.

Keywords:
96-well plate aggregometryLight transmission aggregometryplatelet aggregometry

More Related Videos

A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate
05:46

A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate

Published on: March 7, 2017

11.2K
A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms
07:19

A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms

Published on: October 21, 2010

46.3K

Related Experiment Videos

Last Updated: Feb 13, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

32.3K
A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate
05:46

A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate

Published on: March 7, 2017

11.2K
A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms
07:19

A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms

Published on: October 21, 2010

46.3K

Area of Science:

  • Hematology
  • Biomedical Engineering

Background:

  • Ex vivo light transmission aggregometry (LTA) is the gold standard for assessing platelet reactivity but is costly, time-consuming, and lacks standardization.
  • Significant inter-site variability in LTA results necessitates test repetition, particularly during patient transfers between hospitals.
  • There is a clear need for a more accessible and standardized method for platelet function testing.

Purpose of the Study:

  • To introduce and discuss the methods and applications of 96-well plate aggregometry.
  • To highlight the potential of this novel approach to overcome the limitations of traditional LTA.
  • To emphasize its utility in both research and clinical practice.

Main Methods:

  • Adapting light transmission aggregometry principles to a 96-well plate format compatible with standard plate readers.
  • Utilizing significantly lower platelet volumes per test compared to LTA.
  • Developing lyophilized, standardized agonist plates for reproducible, multi-site testing.

Main Results:

  • The 96-well plate method allows for the assessment of multiple agonist concentrations due to reduced sample requirements.
  • Lyophilized agonist plates provide a stable, portable assay substrate for consistent results across different locations.
  • This approach facilitates standardized and reproducible platelet function testing.

Conclusions:

  • 96-well plate aggregometry presents a practical, standardized, and cost-effective solution for platelet function assessment.
  • This method addresses the limitations of LTA, offering improved accessibility and reproducibility.
  • It holds significant promise for advancing both research and clinical applications in platelet analysis.