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The long noncoding RNA landscape in cardiovascular disease: a brief update
Irene Salamon1,2, Gloria Saccani Jotti3, Gianluigi Condorelli1,2,4
1Department of Cardiovascular Medicine, Humanitas Research Hospital.
Current Opinion in Cardiology
|March 16, 2018
Summary
Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in heart failure. These molecules regulate cardiac remodeling and may offer novel therapeutic targets for cardiovascular diseases.
Area of Science:
- Molecular Biology
- Cardiology
- Genetics
Background:
- Long noncoding RNAs (lncRNAs) are key regulators of cellular processes.
- Their dysregulation is implicated in various pathological conditions, including cardiovascular diseases.
- lncRNAs play a role in myocardial remodeling and stress responses.
Purpose of the Study:
- To review current knowledge on lncRNAs in cardiovascular disease.
- To highlight the specific involvement of lncRNAs in heart failure.
- To explore the therapeutic potential of lncRNAs in cardiovascular conditions.
Main Methods:
- Literature review of recent studies on lncRNAs and cardiovascular disease.
- Analysis of lncRNA involvement in myocardial remodeling processes.
- Synthesis of findings regarding lncRNA regulation in heart failure.
Main Results:
- lncRNAs are dysregulated in pathological conditions affecting the heart.
- They regulate critical cellular responses to stress and myocardial remodeling.
- lncRNAs influence cardiomyocyte hypertrophy, function, and fibroblast proliferation.
Conclusions:
- lncRNAs represent a complex regulatory layer in cardiac development and disease.
- Dysregulated lncRNAs are implicated in the pathophysiology of heart failure.
- lncRNAs hold promise as novel therapeutic targets for cardiovascular diseases.
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