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Viral manipulation of STAT3: Evade, exploit, and injure
Armando Andres Roca Suarez1,2, Nicolaas Van Renne1,2, Thomas F Baumert1,2,3
1Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Plos Pathogens
|March 16, 2018
Summary
Viruses manipulate signal transducer and activator of transcription 3 (STAT3) to evade immune responses, impacting host health and disease. Understanding these interactions could lead to new antiviral therapies targeting STAT3.
Area of Science:
- Immunology
- Virology
- Molecular Biology
Background:
- Signal transducer and activator of transcription 3 (STAT3) is crucial for immune responses and physiological functions.
- Pathogens trigger STAT3 activation, presenting viruses with evolutionary choices: suppress or utilize it.
- Dysregulated STAT3 activity is linked to cancer and other diseases.
Purpose of the Study:
- To review how human viruses interact with STAT3-mediated inflammation.
- To explore the consequences of these viral strategies for the host.
- To discuss the potential of STAT3 as an antiviral therapeutic target.
Main Methods:
- Literature review of viral interactions with STAT3 pathways.
- Analysis of host-pathogen dynamics concerning STAT3.
- Exploration of STAT3's role in viral pathogenesis and immune evasion.
Main Results:
- Viruses have evolved diverse mechanisms to modulate STAT3 signaling.
- Viral manipulation of STAT3 impacts host immune responses and disease progression.
- STAT3's dual role in immunity and disease is highlighted in viral infections.
Conclusions:
- Viral exploitation or inhibition of STAT3 significantly influences host outcomes.
- Targeting STAT3 offers a promising avenue for developing novel antiviral treatments.
- Further research into STAT3-viral interplay is essential for therapeutic advancements.
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