Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Self-Concept

Self-Concept

Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
Infancy and Emerging Recognition
During infancy, self-concept is virtually nonexistent. Babies do not distinguish themselves as separate entities and often mistake their...

Concepts and Prototypes

Concepts and Prototypes

The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
The brain organizes this information using concepts, which are mental categories grouping linguistic data,...

Formula Mass and Mole Concepts of Compounds

Formula Mass and Mole Concepts of Compounds

Formula Mass of Covalent Compounds

Concept of Pressure at a Point

Concept of Pressure at a Point

The concept of pressure at a point in a fluid establishes that pressure within a fluid is uniform in all directions at a specific location. This uniformity occurs because fluid molecules exert force evenly across any point due to their random motion and continuous collisions within the fluid. Pressure at a point is determined by the surrounding fluid molecules and is influenced by factors like depth and density, rather than by shape or orientation.
In a fluid at rest, pressure acts equally in...

Understanding Self-Concept

Understanding Self-Concept

The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...

Basic Concept

Basic Concept

Engineering mechanics is a branch of engineering that studies motion and the forces acting on objects. It is a fundamental subject and forms the basis of many other engineering disciplines. Length, time, mass, and force are some basic concepts in engineering mechanics.
Length, which measures the distance traveled by an object, is a fundamental concept in engineering mechanics. We use coordinates relative to a reference point to describe the distance. Length not only helps to describe the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Physical Basis of Functioning of Antifreeze Protein].

Molekuliarnaia biologiia·2022

Same author

Comparative Analysis of Aggregation of Thermus thermophilus Ribosomal Protein bS1 and Its Stable Fragment.

Biochemistry. Biokhimiia·2020

Same author

[Protein Biosynthesis Proofreading Is Closely Associated with the Existence of Factor-Free Ribosomal Synthesis].

Molekuliarnaia biologiia·2019

Same author

[Intersubunit Mobility of the Ribosome].

Molekuliarnaia biologiia·2019

Same author

50+ Years of Protein Folding.

Biochemistry. Biokhimiia·2018

Same author

[Anomalous Kinetics of Amyloidogenesis Suggest a Competition between Oligomers and Fibrils].

Molekuliarnaia biologiia·2018

Search research articles

Related Experiment Video

Updated: Feb 13, 2026

Molten-Salt Synthesis of Complex Metal Oxide Nanoparticles

Molten-Salt Synthesis of Complex Metal Oxide Nanoparticles

Published on: October 27, 2018

The Molten Globule Concept: 45 Years Later.

V E Bychkova¹, G V Semisotnov, V A Balobanov

¹Institute of Protein Research, Pushchino, Moscow Region, 142290, Russia. uralm62@rambler.ru.

Biochemistry. Biokhimiia

|March 17, 2018

Summary

This review explores the molten globule (MG) state in protein folding, discussing its role in traditional and nontraditional protein systems and the dry molten globule. It offers insights into solving Levinthal's paradox and the functional significance of the MG state.

More Related Videos

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis

Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis

Published on: December 8, 2023

Related Experiment Videos

Last Updated: Feb 13, 2026

Molten-Salt Synthesis of Complex Metal Oxide Nanoparticles

Molten-Salt Synthesis of Complex Metal Oxide Nanoparticles

Published on: October 27, 2018

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis

Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis

Published on: December 8, 2023

Area of Science:

Protein folding dynamics
Biophysical chemistry
Structural biology

Background:

The molten globule (MG) state is a transient protein conformation.
Understanding protein folding pathways is crucial for molecular biology.
Levinthal's paradox highlights the improbability of random protein folding.

Observation:

The MG state has been identified in various traditional protein systems.
New data reveal MG-mediated folding in "nontraditional" proteins.
The existence and properties of the dry molten globule are investigated.

Findings:

The review details systems where the MG state is observed.
It provides a concise explanation for Levinthal's paradox.
New findings on MG-mediated folding and potential functions are presented.

Implications:

The MG state may play a functional role in protein biology.
Understanding MG states can inform the design of novel proteins.
This research contributes to solving fundamental questions in protein folding.