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Factors Affecting Renal Clearance: Renal Impairment01:17

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
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The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
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Direct Drug Delivery to Kidney via the Renal Artery
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Post-PCNL Renal Artery Pseudoanurysm.

Safdar Shah1, Abeer Fatima2, Muhammad Danial Ali Shah3

  • 1Department of Urology, KEMU/Mayo Hospital, Lahore.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|March 17, 2018
PubMed
Summary
This summary is machine-generated.

A renal artery pseudoaneurysm, a rare complication after kidney procedures like PCNL, can cause severe bleeding. This case highlights successful treatment using coil embolization for a patient presenting with massive hematuria post-procedure.

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Area of Science:

  • Urology
  • Interventional Radiology
  • Nephrology

Background:

  • Renal artery pseudoaneurysms are uncommon but serious complications following renal interventions.
  • The incidence is under 1% but may rise with increased use of endoscopic renal procedures.
  • These pseudoaneurysms pose a risk of significant hemorrhage.

Observation:

  • A 30-year-old female underwent percutaneous nephrolithotomy (PCNL) for a renal pelvic stone.
  • Two weeks post-PCNL, she experienced massive hematuria.
  • Renal angiography identified an interlobar artery pseudoaneurysm.

Findings:

  • The interlobar artery pseudoaneurysm was diagnosed via renal angiography.
  • The pseudoaneurysm was successfully treated using endovascular coil embolization.
  • This minimally invasive approach effectively managed the life-threatening complication.

Implications:

  • Coil embolization is an effective treatment for post-procedural renal artery pseudoaneurysms.
  • Early diagnosis and intervention are crucial for managing this complication.
  • The case underscores the importance of vigilance following renal interventions, especially PCNL.