Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thoracic Aorta01:15

Thoracic Aorta

1.8K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.8K
Pressure Relationships in Thoracic Cavity01:24

Pressure Relationships in Thoracic Cavity

6.8K
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
6.8K
Acid Strength and Molecular Structure03:05

Acid Strength and Molecular Structure

33.2K
Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
33.2K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.8K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.8K
Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

6.7K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
6.7K
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

2.8K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amine-Reactive Augmentation of Silk Fibroin Mats for Increasing Cargo Retention Capabilities.

Journal of functional biomaterials·2026
Same author

Clamp On vs Off Impact of Distal Anastomotic Technique During Ascending Aortic Replacement in Acute Type A Aortic Dissection: IRAD Insights.

Interdisciplinary cardiovascular and thoracic surgery·2026
Same author

Focal adhesion proteins confer smooth muscle anoikis resistance and protection against aortic aneurysm and dissection.

JCI insight·2026
Same author

Load Transfer Along Continuous Collagen Fibers Reduces the Importance of Wall Thickness Variations.

Journal of biomechanical engineering·2026
Same author

CT-based visualization of aortic valve morphology: from 3D energy-integrating CT to 4D photon counting CT.

Frontiers in cardiovascular medicine·2026
Same author

"Attractive" Treatment for Abdominal Aortic Aneurysm Repair: Magnetic Localization of Silk-Iron Packaged Extracellular Vesicles.

Journal of functional biomaterials·2025

Related Experiment Video

Updated: Feb 13, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

20.8K

Structural modeling reveals microstructure-strength relationship for human ascending thoracic aorta.

James R Thunes1, Julie A Phillippi2, Thomas G Gleason2

  • 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.

Journal of Biomechanics
|March 17, 2018
PubMed
Summary

Accurate prediction of aortic dissection risk is crucial. A new structural model reveals collagen fiber orientation is key to predicting aortic wall strength and dissection risk in patients with aortic aneurysms.

Keywords:
Aortic dissectionCollagen fiberElastinFinite element analysisStructural modelingUniaxial strength

More Related Videos

Imaging of the Microstructural Failure Mechanism in the Human Hip
08:43

Imaging of the Microstructural Failure Mechanism in the Human Hip

Published on: September 29, 2023

1.4K
Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts
05:58

Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts

Published on: March 29, 2024

1.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

20.8K
Imaging of the Microstructural Failure Mechanism in the Human Hip
08:43

Imaging of the Microstructural Failure Mechanism in the Human Hip

Published on: September 29, 2023

1.4K
Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts
05:58

Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts

Published on: March 29, 2024

1.6K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • High mortality rates associated with aortic dissection underscore the need for improved risk assessment tools.
  • Current surgical intervention guidelines based on aortic diameter (<5.5 cm) are insufficient, as dissections occur at smaller diameters.
  • Understanding the structural basis of aortic wall mechanics is essential for developing better risk stratification metrics.

Purpose of the Study:

  • To develop a structural model of the aortic media to assess its role in dissection risk.
  • To investigate the influence of lamellar structure, elastic lamellae, and collagen fiber networks on in-plane tissue strength.
  • To evaluate how collagen fiber organization impacts dissection initiation from intimal tears.

Main Methods:

  • A structural model of the aortic media's lamellar units was created, incorporating elastic lamellae and collagen fiber networks.
  • Multiphoton imaging was used to derive collagen fiber organization from ascending aortic tissue specimens from three patient groups: control, tricuspid aortic valve (TAV) aneurysm, and bicuspid aortic valve (BAV) aneurysm.
  • Model parameters were calibrated using experimentally measured circumferential tensile strength and validated against longitudinal tensile strength.

Main Results:

  • The structural model demonstrated that collagen fiber orientation significantly influences anisotropic tissue strength in all patient cohorts.
  • Orientation distribution, which dictates the proportion of loaded collagen fibers at a given stretch, was identified as a critical factor.
  • The model successfully predicted tissue strength variations across different patient groups based on their unique collagen organization.

Conclusions:

  • Collagen fiber orientation within the aortic media is a key determinant of tissue strength and, consequently, dissection risk.
  • The developed structural model provides a framework for understanding the biomechanical factors contributing to aortic dissection.
  • This research highlights the potential for improved, evidence-based risk stratification metrics for aortic dissection.