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Kindlins: Roles in development and cancer progression

Jun Zhan1, Hongquan Zhang1

  • 1Peking University Health Science Center, Department of Anatomy, Histology and Embryology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), and State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.

The International Journal of Biochemistry & Cell Biology
|March 17, 2018
PubMed

Insights

Kindlins, FERM domain proteins, are crucial for cell functions and embryonic development. Their dysregulation is linked to various cancers, highlighting their importance in human diseases.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • Kindlins are FERM domain proteins with three members (Kindlin-1, -2, -3) involved in cell migration, proliferation, differentiation, and survival.
  • They interact with β-integrin cytoplasmic tails, playing essential roles in normal development and human diseases, particularly cancers.

Purpose of the Study:

  • To profile Kindlins' roles in embryonic development and cancer progression.
  • To summarize known binding proteins and regulated signaling pathways (Wnt/β-catenin, TGFβ, EGFR, Hedgehog).

Main Methods:

  • Literature review and summarization of existing data on Kindlin family members.
  • Analysis of Kindlin expression patterns in embryonic tissues.
  • Review of Kindlin deregulation in various cancers and other diseases.

Main Results:

  • Kindlin-1 is expressed in endo/ectodermal tissues, Kindlin-2 in mesodermal tissues, and Kindlin-3 in mesodermal and ectodermal tissues during embryonic development.
  • Kindlin deregulation is frequently observed in cancers across different organs.
  • Kindlins are involved in regulating key signaling pathways and are subject to complex regulation, modification, and degradation mechanisms.

Conclusions:

  • Kindlins are critical regulators of embryonic development and cancer progression.
  • Understanding Kindlin biology, including their interactions, signaling pathways, and regulation, is vital for addressing their role in human diseases.
Keywords:
CancerDevelopmentFREMT geneKindlinScaffold protein

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