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Updated: Feb 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Brain Diffusion Abnormalities in Children with Tension-Type and Migraine-Type Headaches

J D Santoro1, N D Forkert2, Q-Z Yang1

  • 1From the Department of Neurology (J.D.S., Q.-Z.Y., S.P.), Division of Child Neurology.

AJNR. American Journal of Neuroradiology
|March 17, 2018
PubMed

Insights

Pediatric tension-type and migraine headaches show early brain diffusion changes, particularly in the hippocampus and brain stem. These findings may precede structural changes seen in adult chronic headache patients.

Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Headache Disorders

Background:

  • Tension-type headache and migraine are common in children.
  • Understanding early brain changes is crucial for pediatric headache management.

Purpose of the Study:

  • Compare regional cerebral volumes and diffusion in pediatric tension-type and migraine headaches.
  • Investigate early neuroimaging markers in childhood headache disorders.

Main Methods:

  • Retrospective review of 32 tension-type and 23 migraine patients.
  • Atlas-based Diffusion Weighted Imaging (DWI) analysis at 3T.
  • Multivariate analysis of covariance to compare patient groups and controls.

Main Results:

  • No significant differences in regional brain volumes were observed.
  • Increased apparent diffusion coefficient (ADC) in the hippocampus and brain stem for both headache types.
  • Migraine patients showed increased ADC in the thalamus and a trend in the amygdala.

Conclusions:

  • Early cerebral diffusion changes are identifiable in pediatric tension-type and migraine headaches.
  • These diffusion alterations may be precursors to structural changes in chronic headache.
  • Findings support nociception mechanisms contributing to pediatric headache pathophysiology.
Abstract

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