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Published on: June 8, 2022
Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to
Alice Huertas1,2, Christophe Guignabert1,2, Joan A Barberà3,4
1INSERM UMR_S 999, Hôpital Marie Lannelongue, Université Paris-Sud/Université Paris-Saclay, AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Plessis-Robinson and Le Kremlin-Bicêtre, France.
Abstract:
The European Respiratory Society (ERS) Research Seminar entitled "Pulmonary vascular endothelium: orchestra conductor in respiratory diseases - highlights from basic research to therapy" brought together international experts in dysfunctional pulmonary endothelium, from basic science to translational medicine, to discuss several important aspects in acute and chronic lung diseases. This review will briefly sum up the different topics of discussion from this meeting which was held in Paris, France on October 27-28, 2016. It is important to consider that this paper does not address all aspects of endothelial dysfunction but focuses on specific themes such as: 1) the complex role of the pulmonary endothelium in orchestrating the host response in both health and disease (acute lung injury, chronic obstructive pulmonary disease, high-altitude pulmonary oedema and pulmonary hypertension); and 2) the potential value of dysfunctional pulmonary endothelium as a target for innovative therapies.
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