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Complete Genome Sequence of the Environmental Burkholderia pseudomallei Sequence Type 131 Isolate MSHR1435,

Jason W Sahl1, Mark Mayo2, Erin P Price2

  • 1Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.

Genome Announcements
|March 17, 2018
PubMed

Insights

This study details the genome of Burkholderia pseudomallei MSHR1435, a virulent ST131 strain linked to chronic melioidosis. This genomic data will aid research into environmental factors, virulence, and long-term B. pseudomallei infections.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Melioidosis is a serious infection caused by Burkholderia pseudomallei.
  • Chronic infections can persist for years, posing significant treatment challenges.
  • Environmental strains of B. pseudomallei, particularly sequence type 131 (ST131), are of growing epidemiological interest.

Purpose of the Study:

  • To present the completed genome sequence of the virulent Burkholderia pseudomallei isolate MSHR1435.
  • To provide a genomic reference for understanding environmental B. pseudomallei ecology.
  • To facilitate research into the mechanisms of virulence and chronic B. pseudomallei infections.

Main Methods:

  • Whole-genome sequencing of the B. pseudomallei MSHR1435 isolate.
  • Bioinformatic analysis of the generated genome data.

Main Results:

  • The complete genome sequence of B. pseudomallei MSHR1435 (ST131) was successfully obtained.
  • This isolate is epidemiologically linked to a 17.5-year chronic melioidosis case.
  • The genome provides a foundational resource for further scientific investigation.

Conclusions:

  • The MSHR1435 genome sequence is a valuable resource for studying B. pseudomallei.
  • This data will advance our understanding of environmental B. pseudomallei, virulence factors, and chronic infection dynamics.

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