Related Experiment Video

Updated: Feb 13, 2026

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
13:50

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat

Published on: February 5, 2011

81.0K

Endovascular recanalisation with drug coated balloon for chronic symptomatic middle cerebral artery total occlusion

Jun Zhang1, Xiao Zhang1, Jin-Ping Zhang1

  • 1Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

BMJ Case Reports
|March 17, 2018
PubMed

Insights

Drug-coated balloons (DCBs) offer a promising treatment for chronic middle cerebral artery (MCA) total occlusion. This case study shows successful revascularization with DCBs, suggesting potential for treating intracranial atherothrombotic stenosis.

Area of Science:

  • Interventional Neurology
  • Vascular Neurology
  • Medical Device Technology

Background:

  • Optimal treatment for chronic symptomatic middle cerebral artery (MCA) total occlusion remains unclear.
  • Stenting shows promise for revascularization but carries a high risk of in-stent restenosis (ISR).
  • Drug-coated balloons (DCBs) are effective for ISR but their use in de novo intracranial stenosis, especially total occlusions, is not well-documented.

Observation:

  • A patient with chronic left MCA total occlusion was treated.
  • The treatment involved the use of drug-coated balloons (DCBs).

Findings:

  • Successful revascularization of the total MCA occlusion was achieved using DCBs.
  • The patient experienced a good outcome at the 1-year follow-up.

Implications:

  • Drug-coated balloons (DCBs) may be a feasible option for treating de novo intracranial atherothrombotic stenosis and total occlusions.
  • Further comparative studies are needed to evaluate DCBs against stenting for intracranial revascularization.
  • This approach could offer an alternative to stenting, potentially reducing ISR complications.

Keywords:
angioplastyballoonstenosis

More Related Videos

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.1K
Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion07:43

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

Published on: February 22, 2013

15.5K

Related Concept Videos

Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
4.2K
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
9.5K
COP Coated Vesicles00:59

COP Coated Vesicles

Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
18.3K
Coat Assembly and GTPases01:33

Coat Assembly and GTPases

Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
4.5K
Total Voids in Concrete01:12

Total Voids in Concrete

Total voids in concrete encompass gel water volume, capillary pores, and entrapped air. Gel water (retained within the cement hydration products) and physically entrapped or adsorbed water are significant for the hydration process. For complete hydration, it's estimated that the space needed for the products of a cubic centimeter of cement doubles. Capillary pores constitute the unoccupied space within the hydrated cement paste, with their size largely influenced by the water-to-cement...
499
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
12.4K