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Updated: Feb 13, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies-associated Vasculitis
Maria Prendecki1,2, Leyre Martin3,4, Anisha Tanna3,4
1From the Imperial College London, London, UK. m.prendecki@imperial.ac.uk.
Objective:
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been linked with thyroid disease as a result of antithyroid medications. We assessed the prevalence of thyroid disease in our patients with AAV.
Methods:
Clinical records of 279 patients with AAV diagnosed between 1991 and 2014 were analyzed.
Results:
Thyroid disease was identified in 21.5% of patients, but only 2 had previously received propylthiouracil. There was a greater proportion of female patients, patients with antimyeloperoxidase antibodies, and patients with renal disease in the group with thyroid disease.
Conclusion:
Our data show a higher prevalence of thyroid disease in patients with AAV than the general population. This was not attributable to antithyroid drugs.
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