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Immunological Status of Children Born to Female Liver Recipients

Agnieszka Drozdowska-Szymczak1, Bronisława Pietrzak2, Natalia Czaplińska1

  • 1Division of Neonatology and Neonatal Intensive Care Unit of First Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Annals of Transplantation
|March 17, 2018
PubMed

Insights

Maternal immunosuppressive therapy after liver transplantation may impact infant immunity. While overall immunoglobulin levels showed no significant difference, specific IgA and IgM concentrations varied based on the type of calcineurin inhibitor used by the mother.

Area of Science:

  • Immunology
  • Transplantation
  • Pediatrics

Background:

  • Maternal immunosuppressive treatment in organ recipients can influence fetal and newborn immune system development.
  • Liver transplantation requires long-term immunosuppression, posing potential risks to offspring immunity.

Purpose of the Study:

  • To evaluate the impact of maternal immunosuppressive therapy post-liver transplantation on the immune system parameters of their children.
  • To compare immunoglobulin levels (IgG, IgM, IgA) in children born to liver recipients versus a control group.

Main Methods:

  • Study included 52 children of liver recipients and 52 controls, aged 1 day to 10 years.
  • Serum concentrations of IgG, IgM, and IgA were measured using immune agglutination on a Cobas 6000 analyzer.
  • Analysis considered age and maternal immunosuppressive drug type (tacrolimus vs. cyclosporine).

Main Results:

  • No significant differences in mean IgG, IgM, and IgA levels were observed between children of liver recipients and the control group.
  • A significant difference in IgA concentration distribution was noted compared to normal values (p<0.05).
  • Mean IgA (p<0.05) and IgM (p<0.05) concentrations differed based on maternal calcineurin inhibitor type (tacrolimus or cyclosporine).

Conclusions:

  • The type of immunosuppressive therapy (calcineurin inhibitor) used during pregnancy may influence specific immune parameters in children.
  • Further research is necessary to confirm the observed effects of maternal immunosuppression on offspring immunity.

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