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Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells
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Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells

Published on: January 19, 2011

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Voltage gating of mechanosensitive PIEZO channels

Mirko Moroni1, M Rocio Servin-Vences2, Raluca Fleischer2

  • 1Department of Neuroscience, Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092, Berlin, Germany. mirko.moroni@mdc-berlin.de.

Nature Communications
|March 17, 2018
PubMed
Summary

PIEZO ion channels, essential for physiology, are modulated by voltage, not just mechanical stimuli. This voltage sensitivity, especially in older PIEZO proteins, adds a regulatory mechanism for channel activation.

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