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Updated: Feb 13, 2026
18:48
Murine Renal Transplantation Procedure
Published on: July 10, 2009
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Recurrent primary hyperoxaluria type 2 leads to early post-transplant renal function loss: A case report
Si Liu1, Baoshan Gao1, Gang Wang1
1Department of Urology, Transplant Center, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Experimental and Therapeutic Medicine
|March 17, 2018
Summary
Primary hyperoxaluria type 2, a rare genetic disorder, causes kidney stones. Early diagnosis and combined liver-kidney transplant are crucial for effective treatment in unresponsive cases.
Area of Science:
- Genetics
- Nephrology
- Biochemistry
Background:
- Primary hyperoxaluria type 2 (PH2) is a rare autosomal recessive metabolic disorder.
- It results from glyoxylate reductase/hydroxypyruvate reductase deficiency, leading to oxalate overproduction.
- PH2 is characterized by recurrent nephrolithiasis and nephrocalcinosis, causing significant kidney damage.
Purpose of the Study:
- To report a case of PH2 in a patient unresponsive to conventional treatments.
- To highlight the diagnostic challenges and treatment outcomes for PH2.
- To emphasize the potential need for combined liver-kidney transplantation.
Main Methods:
- Case report of a 33-year-old male patient with PH2.
- Review of patient's medical history, treatment responses, and diagnostic investigations.
- Description of the renal transplantation procedure and outcomes.
Main Results:
- The patient presented with recurrent nephrolithiasis and did not respond to standard therapies.
- Renal transplantation was performed due to the severity of the condition.
- The case underscores the importance of considering PH2 in patients with refractory nephrolithiasis.
Conclusions:
- Hyperoxaluria should be suspected in patients with recurrent nephrolithiasis, especially those resistant to conventional treatments.
- Blood oxalate levels and stone composition analysis are vital diagnostic tools.
- Combined liver-kidney transplantation may be necessary for successful management of PH2, as kidney transplant alone may be insufficient.
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