Related Experiment Video
Updated: Feb 13, 2026
07:41
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
2.9K
An integrated approach identifies new oncotargets in melanoma
Daniela Cecconi1, Luca Dalle Carbonare2, Antonio Mori3
1Department of Biotechnology, Mass Spectrometry and Proteomics Lab, University of Verona, 37134 Verona, Italy.
Oncotarget
|March 17, 2018
Summary
Researchers identified novel oncotargets for melanoma, a skin cancer. Single stranded DNA binding protein 1 (SSBP1) was found to be a potential onco-suppressor, offering new avenues for melanoma treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Melanoma is an aggressive skin cancer with complex genetic underpinnings.
- Early detection is crucial for improving melanoma patient prognosis.
- Understanding melanoma transformation pathways can reveal novel therapeutic targets.
Purpose of the Study:
- To identify novel oncotargets for melanoma using an integrated multi-omics approach.
- To investigate the molecular mechanisms of ascorbic acid's anti-cancer effects in melanoma cells.
- To evaluate the role of identified genes in melanoma cell transformation and migration.
Main Methods:
- Proteomic analysis of melanoma cells treated with ascorbic acid.
- Gene expression profiling and bioinformatic analysis.
- Evaluation of gene expression and cell migration in multiple melanoma cell lines.
Main Results:
- Ascorbic acid treatment revealed deregulated processes and potential biomarkers in melanoma.
- Key genes involved in melanoma cell transformation include Enolase 1 (ENO1), Parkinsonism-associated deglycase (PARK7), Prostaglandin E synthase 3 (PTGES3), Nucleophosmin (NPM1), and Stathmin 1 (STMN1).
- Single stranded DNA binding protein 1 (SSBP1) was identified as a potential onco-suppressor in melanoma.
Conclusions:
- The study identified several novel genes implicated in melanoma pathogenesis and progression.
- SSBP1 shows promise as a tumor suppressor, warranting further investigation for therapeutic potential.
- An integrated approach combining proteomics, gene expression, and bioinformatics is effective for discovering melanoma biomarkers.
Related Concept Videos
01:26Integration by Parts: Indefinite Integrals
230
Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
230
01:23Integration by Parts: Definite Integrals
92
Definite integrals involving the product of two functions over a fixed interval can be evaluated using integration by parts. This method rewrites the integral as the difference of a product evaluated at the endpoints and a remaining definite integral that is often simpler to compute.A representative example is the definite integral of the inverse tangent function. Since there is no direct integration formula for arctan x, the integrand is rewritten as a product of arctan x and the...
92
02:39The Integrated Rate Law: The Dependence of Concentration on Time
43.8K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
43.8K
01:20Frustration and Conflict: Approach-Approach, Approach-Avoidance
544
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
544
01:29Definite Integral
81
Consider a real-valued function defined on a closed interval. One of the fundamental objectives in calculus is to determine the area under the graph of such a function. When an exact computation is not readily available, this area can be estimated by dividing the interval into a finite number of equal subintervals. Each subinterval corresponds to a rectangle whose width is the length of the subinterval and whose height is determined by the value of the function at a selected point within that...
81
01:25Indefinite Integrals
75
The water inflow rate into a storage tank is not constant but increases over time. Initially, the pump delivers water at a rate of 5 L/min. However, the inflow rate increases by 2 L/min for each additional minute due to rising pressure or system adjustments. This scenario can be described mathematically by a linear function:It is necessary to integrate the inflow rate function to measure the total volume of water added to the tank over time. The total water volume V(t) is obtained by performing...
75