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Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to

Emeli Månsson1,2,3, Berolla Sahdo2, Åsa Nilsdotter-Augustinsson4

  • 1School of Medical Sciences.

Journal of Bone and Joint Infection
|March 17, 2018
PubMed

Insights

Staphylococcus epidermidis from prosthetic joints trigger lower caspase-1 activation in neutrophils compared to skin strains. This suggests a potential host-specific inability to fight certain S. epidermidis infections.

Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Nosocomial Staphylococcus epidermidis strains are prevalent in prosthetic joint infections (PJIs).
  • Neutrophil caspase-1 activation is crucial for inflammatory responses to bacterial pathogens.

Purpose of the Study:

  • To investigate differences in caspase-1 activation in human neutrophils upon exposure to Staphylococcus epidermidis from PJIs versus normal skin flora.
  • To explore potential host- and isolate-dependent variations in immune response.

Main Methods:

  • Human neutrophils were incubated with Staphylococcus epidermidis isolates from PJIs and commensal skin flora.
  • Levels of active caspase-1 in neutrophils were measured and compared between groups.

Main Results:

  • Lower active caspase-1 levels were observed in neutrophils incubated with PJI-derived S. epidermidis compared to commensal isolates.
  • Significant differences in caspase-1 activation were noted, dependent on both the host and the specific bacterial isolate.

Conclusions:

  • Certain strains of S. epidermidis from PJIs may evade a robust neutrophil caspase-1 response.
  • A host-dependent incapacity to elicit a strong caspase-1 response towards specific S. epidermidis strains is suggested.
  • Further research with larger cohorts is recommended to validate these findings.
Keywords:
Staphylococcus epidermidiscaspase-1neutrophilsprosthetic joint infections, host-pathogen interaction

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