Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.0K
Structural Protein Function01:56

Structural Protein Function

3.3K
3.3K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.4K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.4K
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

6.1K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
6.1K
Structure and Function of Platelets01:18

Structure and Function of Platelets

3.7K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.7K
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

4.5K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycosylated extracellular matrix drives immune suppression by modulating macrophage-T cell crosstalk in triple-negative breast cancer.

Nature communications·2026
Same author

Synthetic Inducible Bacteria Normalize the Microenvironment of Refractory Tumors, Potentiating Checkpoint Inhibitor Responses.

Molecular cancer therapeutics·2026
Same author

Synthetic inducible bacteria normalize the microenvironment of refractory tumors, potentiating checkpoint inhibitor responses.

Molecular cancer therapeutics·2026
Same author

Multi-omics qualification of an organ-on-a-chip model of osteolytic bone metastasis.

Acta biomaterialia·2025
Same author

Tumor's Digest: Macrophage Metabolism Creates a Barrier to T Cells.

Cancer research·2024
Same author

Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate.

Cancer research communications·2024

Related Experiment Video

Updated: Feb 13, 2026

Author Spotlight: MAPP Protocol – Advancing Glycan Analysis
07:12

Author Spotlight: MAPP Protocol – Advancing Glycan Analysis

Published on: September 29, 2023

2.4K

Cancer glycan epitopes: biosynthesis, structure and function.

Oliver M T Pearce1

  • 1Centre for Cancer & Inflammation, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.

Glycobiology
|March 17, 2018
PubMed
Summary

Aberrant cancer glycan epitopes are key to malignancy. Understanding their regulation and exploring glycoforms and patterns offers new diagnostic and therapeutic targets for cancer.

Area of Science:

  • Biochemistry
  • Glycobiology
  • Cancer Biology

Background:

  • Aberrant glycan epitopes are hallmarks of cancer, but their regulatory mechanisms and clinical utility are not fully understood.
  • Current understanding of cancer glycan epitopes is limited, hindering their application in diagnostics and therapeutics.

Purpose of the Study:

  • To review cancer glycan epitopes, focusing on biosynthesis, structure, and role in cancer progression.
  • To discuss the application of cancer glycan epitopes and glycoforms as biomarkers and therapeutic targets.
  • To introduce emerging concepts of glycan patterns and the glycocalyx in cancer.

Main Methods:

  • Literature review of major glycan classes in cancer.
  • Analysis of glycan biosynthesis, structure, and function in malignancy.

More Related Videos

Analysis of N-glycans from Raphanus sativus Cultivars Using PNGase H+
08:26

Analysis of N-glycans from Raphanus sativus Cultivars Using PNGase H+

Published on: June 25, 2018

7.1K
Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.1K

Related Experiment Videos

Last Updated: Feb 13, 2026

Author Spotlight: MAPP Protocol – Advancing Glycan Analysis
07:12

Author Spotlight: MAPP Protocol – Advancing Glycan Analysis

Published on: September 29, 2023

2.4K
Analysis of N-glycans from Raphanus sativus Cultivars Using PNGase H+
08:26

Analysis of N-glycans from Raphanus sativus Cultivars Using PNGase H+

Published on: June 25, 2018

7.1K
Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.1K
  • Discussion of current and emerging applications in cancer diagnostics and therapeutics.

    • Main Results:

    • Cancer glycan epitopes are diverse, with specific structures linked to malignant transformation.
    • Cancer glycoforms offer advantages over individual glycans or proteins for biomarker development.
    • New approaches consider glycan patterns and the entire glycocalyx for novel targets.

    Conclusions:

    • A comprehensive understanding of cancer glycan epitope regulation is crucial for clinical translation.
    • Glycoforms and glycan patterns represent promising avenues for developing advanced cancer biomarkers and therapeutics.
    • Emerging concepts in cancer glycobiology are expanding the scope of targets for bench and clinical development.