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Establishment of age- and gender-specific pediatric reference intervals for liver function tests in healthy Han

Xin Li1, Di Wang1, Chun Yang1

  • 1Department of Laboratory Medicine, First Hospital of Jilin University, Xinmin Street No. 71, Changchun, 130021, China.

World Journal of Pediatrics : WJP
|March 17, 2018
PubMed

Insights

Pediatric liver function test reference intervals vary significantly by age and gender in Han children. Establishing accurate pediatric reference intervals requires careful age and gender-specific partitioning for reliable clinical interpretation.

Area of Science:

  • Pediatric Medicine
  • Clinical Biochemistry
  • Biostatistics

Background:

  • Childhood development significantly impacts liver function test (LFT) values.
  • Existing LFT reference intervals may not accurately reflect pediatric physiology.
  • Establishing specific pediatric LFTs is crucial for accurate diagnosis and monitoring.

Purpose of the Study:

  • To establish age- and gender-specific pediatric reference intervals for key liver function tests.
  • To investigate the influence of age and gender on LFTs in healthy Han children.
  • To provide validated reference ranges for clinical use in pediatric populations.

Main Methods:

  • Recruited 1394 healthy Han children aged 2-14 years.
  • Measured serum alanine aminotransferase (ALT), AST, GGT, ALP, TP, ALB, TBIL, and DBIL.
  • Utilized Harris and Boyd's test for partitioning and nonparametric rank method for calculation, with validation in five hospitals.

Main Results:

  • All LFTs showed age-related variations, necessitating age partitioning.
  • Serum ALT, AST, GGT, and ALP required gender-specific partitioning.
  • Specific trends observed: TP, TBIL, DBIL increased; AST decreased; ALT, GGT, ALP, ALB showed complex changes, with notable gender differences in adolescents.

Conclusions:

  • Significant age and gender variations exist in pediatric LFT reference intervals.
  • Age and gender partitioning are essential for establishing accurate pediatric reference intervals.
  • Validated reference intervals improve the reliability of LFT interpretation in children.
Abstract

Keywords:
AgeGenderLiver function testsPediatricReference intervals

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