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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant I: Introduction

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Kidney Transplant II: Surgical Procedure

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Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

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Methods of Sterilization I: Physical Methods

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Related Experiment Video

Updated: Feb 13, 2026

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

Schwann Cell Transplantation Methods Using Biomaterials.

Christine D Plant¹, Giles W Plant²

¹Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|March 17, 2018

Summary

Biomaterials support Schwann cell transplantation for nervous system repair. These materials, natural or synthetic, enhance cell survival, integration, and growth, aiding both in vitro and in vivo strategies.

Keywords:

Biomaterials Collagen Fibrinogen Laminin Matrigel Schwann cells

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Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

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In Vivo Gene Transfer to Schwann Cells in the Rodent Sciatic Nerve by Electroporation

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Published on: September 8, 2016

Area of Science:

Biomaterials science
Neuroscience
Cellular transplantation

Background:

Schwann cells are crucial for nervous system repair.
Cellular transplantation strategies require supportive biomaterials.
Schwann cell survival and integration are key challenges in transplantation.

Purpose of the Study:

To explore the use of biomaterials in Schwann cell transplantation.
To evaluate natural and man-made matrices for Schwann cell delivery.
To assess the role of biomaterials in promoting cell survival and function.

Main Methods:

Incorporation of Schwann cells into natural and synthetic biomaterial matrices.
In vitro assessment of cell integration, proliferation, and differentiation.
In vivo evaluation of biomaterial-assisted Schwann cell transplantation.

Main Results:

Biomaterials provide essential substrates, preventing anoikis (substrate-deprived cell death).
Engineered biomaterials with specific ligands enhance Schwann cell proliferation and differentiation.
Both natural and man-made matrices demonstrate potential for supporting Schwann cell transplantation.

Conclusions:

Biomaterials are versatile tools for enhancing Schwann cell transplantation efficacy.
Tailored biomaterial design can optimize cell survival, integration, and functional recovery.
This work supports the development of advanced strategies for nervous system regeneration.