Related Experiment Video
Updated: Feb 13, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Preliminary design of the internal geometry in a minimally invasive left ventricular assist device under
P Alex Smith1, Yaxin Wang1, Ralph W Metcalfe2
11 Texas Heart Institute, Houston, TX, USA.
Purpose:
A minimally invasive, partial-assist, intra-atrial blood pump has been proposed, which would unload the left ventricle with a flow path from the left atrium to the arterial system. Flow modulation is a common strategy for ensuring washout in the pump, but it can increase power consumption because it is typically achieved through motor-speed variation. However, if a pump's performance curve had the proper gradient, flow modulation could be realized passively. To achieve this goal, we propose a pump performance operating curve as an alternative to the more standard operating point.
Methods And Results:
Mean-line theory was employed to generate an initial set of geometries that were then tested on a hydraulic test rig at ~20,000 r/min. Experimental results show that the intra-atrial blood pump performed below the operating region; however, it was determined that smaller hub diameter and longer chord length bring the performance of the intra-atrial blood pump device closer to the operating curve.
Conclusion:
We found that it is possible to shape the pump performance curve for specifically targeted gradients over the operating region through geometric variations inside the pump.
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08:34Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
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