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Plant Hormones01:56

Plant Hormones

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Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
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Growth hormone - past, present and future.

Michael B Ranke1, Jan M Wit2

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Growth hormone (GH) research has evolved over a century, from early observations to recombinant therapies for growth disorders. Future treatments may target the GH-IGF axis for improved efficacy and safety.

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Area of Science:

  • Endocrinology
  • Pediatrics
  • Molecular Biology

Background:

  • Growth hormone (GH) research spans over 100 years.
  • Early studies focused on GH structure and metabolic effects.
  • Pituitary-derived GH use (1958-1985) elucidated GH-IGF axis regulation and its role in pediatric GH deficiency (GHD).

Purpose of the Study:

  • To review the historical progression of GH research.
  • To highlight the clinical application of GH in growth disorders.
  • To focus on the evolution of GH therapy in childhood conditions.

Main Methods:

  • Historical review of scientific literature.
  • Analysis of clinical observations and studies.
  • Examination of advancements in molecular genetics and recombinant technology.

Main Results:

  • Understanding of GH structure, function, and regulation has significantly advanced.
  • Recombinant human GH is now a standard treatment for GHD and other conditions.
  • The GH-IGF axis is central to growth and metabolism.

Conclusions:

  • GH research has transformed the treatment of growth disorders.
  • Current recombinant GH therapy has safety considerations.
  • Future therapeutics may involve novel approaches targeting the GH-IGF axis.