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Ultrasonic Assessment of Myocardial Microstructure
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RETINAL MICROSTRUCTURE IN POEMS SYNDROME.
Ryutaro Tomita1, Tetsuju Sekiryu1, Hiroaki Shintake2
1Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan; and.
Retinal Cases & Brief Reports
|March 17, 2018
Summary
This case report highlights how adaptive optics imaging detected retinal changes in POEMS syndrome with serous retinal detachment. These changes resolved after treatment, demonstrating AO
Area of Science:
- Ophthalmology
- Neurology
- Hematology
Background:
- Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystem disorder.
- Serous retinal detachment is an ocular manifestation that can occur in POEMS syndrome.
- Multimodal imaging, including spectral domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging, aids in the diagnosis and monitoring of ocular conditions.
Observation:
- A 67-year-old woman with POEMS syndrome presented with bilateral serous retinal detachment.
- SD-OCT revealed hyperreflective foci in the inner retina.
- AO imaging identified numerous low-reflective dots in the affected retina.
Findings:
- Low-reflective dots observed via AO imaging correlated with serous retinal detachment in POEMS syndrome.
- Hyperreflective foci on SD-OCT and low-reflective dots on AO imaging resolved after three months of hematological treatment.
- AO imaging provides high-resolution visualization of retinal microstructures in vivo.
Implications:
- AO imaging may serve as a valuable tool for detecting and monitoring retinal microstructural changes associated with POEMS syndrome.
- The resolution of these retinal findings post-treatment suggests their potential as biomarkers for disease activity and therapeutic response.
- This case underscores the importance of comprehensive ophthalmic evaluation in patients with POEMS syndrome.
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