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Updated: Feb 13, 2026
13:25
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
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Nephrotoxicity: Evidence in Patients Receiving Cisplatin Therapy
Elizabeth A Duffy1, Wendy Fitzgerald2, Kelley Boyle3
1University of Michigan.
Clinical Journal of Oncology Nursing
|March 17, 2018
Summary
Cisplatin chemotherapy can cause kidney damage (nephrotoxicity). Proper hydration and diuresis, along with magnesium and mannitol, may help prevent this, especially in adults. More pediatric research is needed.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- Cisplatin is a widely used chemotherapy agent for various cancers.
- Nephrotoxicity is a significant dose-limiting side effect of cisplatin treatment.
- Hydration and diuresis are established methods to mitigate cisplatin-induced nephrotoxicity.
Purpose of the Study:
- To identify and summarize best practices for supportive care in patients undergoing cisplatin therapy.
- To provide evidence-based recommendations for hydration and diuresis protocols.
- To address the prevention of cisplatin-related nephrotoxicity.
Main Methods:
- A systematic literature search was conducted to identify relevant research.
- Evidence from 22 adult studies was synthesized and critically appraised.
- A single pediatric study was identified for review.
Main Results:
- Hydration is essential for preventing cisplatin-induced nephrotoxicity.
- Magnesium and mannitol administration may support renal function and reduce nephrotoxicity in adults.
- Limited evidence exists for pediatric populations, necessitating further research.
Conclusions:
- Optimizing hydration and diuresis are crucial supportive care strategies for cisplatin chemotherapy.
- Magnesium and mannitol show potential as adjunct therapies for nephroprotection in adults.
- Further investigation is required to establish effective interventions for pediatric patients.
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