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Improved spatial localization in magnetic resonance spectroscopic imaging with two-dimensional PSF-Choice encoding.

Shelley HuaLei Zhang1, Stephan E Maier2, Lawrence P Panych1

  • 1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|March 17, 2018
PubMed
Summary

The two-dimensional PSF-Choice technique significantly reduces signal contamination in magnetic resonance spectroscopic imaging (MRSI). This method improves spatial localization by constraining the point-spread-function (PSF), leading to clearer spectroscopic images.

Keywords:
Fourier encodingGibbs ringingPSF-Choice encodingPoint spread functionProstateRF encodingSpectroscopic imagingVoxel bleeding

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Area of Science:

  • Medical Imaging
  • Spectroscopy
  • Biophysics

Background:

  • Magnetic resonance spectroscopic imaging (MRSI) at low spatial resolution often exhibits signal contamination from adjacent voxels due to ringing artifacts.
  • Improved spatial localization is crucial for accurate MRSI analysis, particularly in complex biological tissues.

Purpose of the Study:

  • To demonstrate the effectiveness of the two-dimensional PSF-Choice technique for enhancing spatial localization in MRSI.
  • To reduce signal contamination and truncation artifacts in MRSI data.

Main Methods:

  • The PSF-Choice technique was implemented using a Point REsolved SpectroScopy (PRESS)-type sequence, modified for two-dimensional excitation.
  • RF excitation pulses were manipulated across phase-encode steps to achieve a desired two-dimensional Gaussian point-spread-function (PSF).
  • The method was validated mathematically and experimentally using phantoms with prostate-relevant metabolites (choline, creatine, citrate) and an oil-surrounded boundary.

Main Results:

  • PSF-Choice encoding demonstrated significantly less signal contamination from the surrounding oil compared to standard phase encoding in a prostate phantom.
  • Standard phase encoding showed significant differences in metabolite ratios (Choline+Creatine to Citrate) near the phantom boundary, unlike PSF-Choice.
  • No significant differences in metabolite ratios were observed with PSF-Choice encoding, even near the boundary, compared to reference values.

Conclusions:

  • The two-dimensional PSF-Choice technique substantially reduces truncation artifacts and spectral contamination in MRSI.
  • This method offers improved spatial localization, leading to more accurate spectroscopic data, especially at tissue-tissue or tissue-background interfaces.