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Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways

Po-Han Chen1,2,3, Jen-Tsan Chi2,3, Michael Boyce1

  • 1Department of Biochemistry.

Glycobiology
|March 17, 2018
PubMed

Insights

O-linked β-N-acetylglucosamine (O-GlcNAc) modification is crucial for cellular stress responses in animals. This review highlights the intricate relationship between O-GlcNAcylation and oxidative stress, focusing on key signaling pathways and metabolism.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Physiology

Background:

  • Thousands of intracellular proteins in metazoans undergo O-linked β-N-acetylglucosamine (O-GlcNAc) modification.
  • O-GlcNAcylation plays a significant role in cellular responses to various stimuli and stresses.
  • A complex interplay between O-GlcNAcylation and oxidative stress is increasingly recognized.

Purpose of the Study:

  • To review the current literature on the connections between O-GlcNAc and oxidative stress.
  • To emphasize the role of O-GlcNAc in major signaling pathways involved in stress response.
  • To illuminate the integration of protein glycosylation and stress responses in animal cell physiology.

Main Methods:

  • Literature review of existing research on O-GlcNAcylation and oxidative stress.
  • Analysis of signaling pathways including KEAP1/NRF2, FOXO, NFκB, and p53.
  • Examination of the impact on cell metabolism.

Main Results:

  • O-GlcNAcylation is intricately linked with oxidative stress responses.
  • Key signaling pathways are modulated by O-GlcNAc modification under stress conditions.
  • Cellular metabolism is influenced by the interplay between O-GlcNAc and oxidative stress.

Conclusions:

  • Protein glycosylation, specifically O-GlcNAcylation, is a critical regulator of cellular signaling and stress responses.
  • Understanding the O-GlcNAc-oxidative stress axis provides insights into animal cell physiology.
  • This integration is vital for effective mechanisms of stress response.

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