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Related Experiment Video

Updated: Feb 13, 2026

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Origin of Gliomas.

Daniel Cahill1, Sevin Turcan2

  • 1Massachusetts General Hospital Brain Tumor Center, Boston, Massachussetts.

Seminars in Neurology
|March 17, 2018
PubMed
Summary

Malignant glioma, a common brain tumor, is largely incurable. Research is advancing understanding of its origins, genetic risks, and evolution to improve treatments and early detection.

Area of Science:

  • Neuro-oncology
  • Cancer biology
  • Genetics

Background:

  • Malignant glioma is a prevalent and often fatal brain tumor.
  • The precise cell of origin for gliomas is still unknown.
  • Significant progress has been made in understanding gliomagenesis.

Purpose of the Study:

  • To review current knowledge on glioma origins and development.
  • To summarize epidemiological data and genetic risk factors.
  • To discuss insights from mouse models of glioma.

Main Methods:

  • Review of population epidemiology studies.
  • Analysis of genetic sequencing data.
  • Examination of genetically engineered mouse models.

Main Results:

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  • Gliomagenesis involves complex population, heritable, and somatic events.
  • Mouse models provide valuable insights into early tumor development.
  • Understanding early events is crucial for therapeutic strategies.

Conclusions:

  • Further research into early cellular events and microenvironments is needed.
  • Enhanced knowledge can lead to better treatment and early detection methods.
  • Targeting early gliomagenesis holds promise for future therapies.