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Updated: Feb 13, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

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Published on: January 9, 2019

Gliomas in Children.

Mariella G Filbin^1,2,3, Dominik Sturm^4,5,6

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Cancer Center, Boston, Massachusetts.

Seminars in Neurology

|March 17, 2018

Summary

This summary is machine-generated.

Pediatric gliomas, common brain tumors in children, arise from specific developmental cells. Understanding their molecular features aids in developing targeted therapies for low- and high-grade gliomas.

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Area of Science:

Pediatric neuro-oncology
Central nervous system (CNS) tumor biology
Developmental neurobiology

Background:

Gliomas are the most frequent primary brain tumors in children and adolescents.
They originate from glial progenitor or stem cells during CNS development.
Specific oncogenic events during critical developmental windows lead to distinct glioma subtypes.

Purpose of the Study:

To review diagnostic features and molecular alterations in pediatric low- and high-grade gliomas.
To explore how molecular insights can inform future targeted therapeutic strategies.
To delineate biologically relevant subgroups based on genetic and epigenetic characterization.

Main Methods:

Review of current literature on pediatric gliomas.
Analysis of diagnostic criteria and classification systems (WHO grades).
Examination of genetic and epigenetic profiling studies.

Main Results:

Pediatric gliomas can be broadly classified into low-grade (WHO I-II) and high-grade (WHO III-IV) types.
Genetic and epigenetic characterization has identified distinct molecular subgroups.
Potentially targetable molecular alterations have been discovered in certain glioma subtypes.

Conclusions:

Understanding the molecular landscape of pediatric gliomas is crucial for accurate diagnosis and subtyping.
Molecular alterations offer promising targets for novel therapeutic interventions.
Future research should focus on translating these findings into effective, targeted treatments for pediatric glioma patients.