Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

801
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
801
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

1.1K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.1K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Reversible and Irreversible Processes01:14

Reversible and Irreversible Processes

5.9K
The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...
5.9K
Diode: Reverse bias01:14

Diode: Reverse bias

2.1K
A diode is reverse-biased when the positive terminal of an external voltage source is connected to the n-type material and the negative terminal to the p-type material. This configuration opposes the natural direction of current flow through the diode, effectively increasing the width of the depletion region and the barrier potential. The reverse bias condition produces a minimal leakage current, primarily due to minority charge carriers. This leakage becomes significant when the reverse...
2.1K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.6K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct probabilistic quantification of mosaic loss of chromosome Y from sequencing data.

bioRxiv : the preprint server for biology·2026
Same author

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA.

Developmental cell·2026
Same author

How long can humans live? All evidence points to a maximum of 125 years.

Nature·2026
Same author

Mutagen-induced somatic mutation rate in primary mammalian cells in relation to maximum life span.

Geromedicine·2026
Same author

The aging genome exhibits organized vulnerability to somatic mutations.

bioRxiv : the preprint server for biology·2026
Same author

Evidence for negative selection against somatic mutations induced in normal fibroblasts by <i>N</i>-ethyl-<i>N</i>-nitrosourea.

Genome research·2026

Related Experiment Video

Updated: Feb 13, 2026

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
10:58

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

Published on: August 29, 2013

11.7K

Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities.

Jean M Hébert1, Jan Vijg2

  • 1Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Trends in Neurosciences
|March 18, 2018
PubMed
Summary

Cell replacement therapy offers a novel approach to combat brain aging. This strategy explores reversing age-related cognitive decline by replacing brain cells, particularly in the neocortex, while preserving function.

Keywords:
age-related damageneocortexneural stem cellregenerationrejuvenationtransplant

More Related Videos

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders
06:12

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

Published on: September 6, 2024

2.1K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.3K

Related Experiment Videos

Last Updated: Feb 13, 2026

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
10:58

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

Published on: August 29, 2013

11.7K
Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders
06:12

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders

Published on: September 6, 2024

2.1K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.3K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Aging Research

Background:

  • Current antiaging strategies targeting druggable pathways show limited success.
  • Cell, tissue, and organ replacement present an alternative for addressing age-induced damage.
  • The brain's amenability to replacement therapies, crucial for self-identity, remains largely unexplored.

Purpose of the Study:

  • To evaluate progressive cell replacement as a strategy to reverse brain aging.
  • To explore the potential of reversing age-related cognitive decline without compromising brain function.
  • To focus on the neocortex, the brain region responsible for higher cognitive functions.

Main Methods:

  • Conceptual analysis of cell replacement strategies for brain aging.
  • Review of existing knowledge on neocortical development, plasticity, and neuronal integration.
  • Identification of challenges and research gaps in brain cell replacement therapies.

Main Results:

  • Limited success of current antiaging drug strategies.
  • Potential of cell replacement to address age-related damage.
  • Significant challenges exist for brain cell replacement, particularly concerning self-identity and functional integration.

Conclusions:

  • Progressive cell replacement is a potential avenue for reversing brain aging.
  • Further research is needed to overcome challenges in functional integration and preserving self-identity.
  • The neocortex is a key focus area due to its role in cognition and existing knowledge base.