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Quantitative baseline CT plaque characterization of unrevascularized non-culprit intermediate coronary stenosis

Mengmeng Yu1, Wenbin Li1, Zhigang Lu2

  • 1Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China.

International Journal of Cardiology
|March 18, 2018
PubMed

Insights

Low attenuation plaque (LAP) in non-culprit coronary lesions predicts lesion progression and major adverse cardiac events (MACE). This finding highlights LAP as a key indicator for assessing cardiac risk in intermediate coronary stenosis.

Area of Science:

  • Cardiovascular Imaging
  • Interventional Cardiology
  • Radiology

Background:

  • Intermediate coronary stenosis requires accurate risk stratification to prevent adverse cardiac events.
  • Coronary CT angiography (CCTA) provides detailed plaque characterization, aiding in risk assessment.

Purpose of the Study:

  • To quantitatively assess baseline CCTA plaque characteristics of unrevascularized non-culprit intermediate coronary stenosis.
  • To determine the association between these plaque features, lesion volume progression, and long-term cardiac prognosis.

Main Methods:

  • Prospective enrollment of patients with intermediate coronary stenosis undergoing CCTA and invasive coronary angiography (ICA).
  • Follow-up CCTA at 1-1.5 years to assess lesion volume progression.
  • Analysis of high-risk plaque features and quantitative measurements, including low attenuation plaque (LAP).

Main Results:

  • Low attenuation plaque (LAP) was more prevalent in lesions that progressed in volume and in patients who experienced major adverse cardiac events (MACE).
  • LAP was identified as an independent predictor for both lesion volume progression (OR=16.74) and MACE (OR=4.25).
  • No significant differences were observed in other quantitative plaque parameters between subgroups.

Conclusions:

  • The presence of LAP in unrevascularized intermediate coronary stenosis is linked to lesion progression.
  • LAP serves as an independent predictor for the occurrence of MACE, indicating its prognostic value.
Abstract

Keywords:
AngiographyCoronary artery diseaseMultidetector computed tomographyPercutaneous coronary interventionPlaque

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