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Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and

Osasenaga Macdonald Ighodaro1, Abiola Mohammed Adeosun1, Oluseyi Adeboye Akinloye2

  • 1Department of Biochemistry, Faculty of Sciences, Lead City University, Ibadan, Nigeria; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta (FUNAAB), Abeokuta, Nigeria.

Medicina (Kaunas, Lithuania)
|March 18, 2018
PubMed

Insights

This review examines alloxan

Area of Science:

  • Biomedical Sciences
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus disrupts glycemic homeostasis, leading to severe complications.
  • Diabetic complications contribute significantly to morbidity and mortality.
  • Assessing antidiabetic compounds relies on their ability to restore glucose balance.

Purpose of the Study:

  • To review the use of alloxan as a diabetogenic agent in animal studies.
  • To investigate the surprising trend in alloxan versus streptozotocin usage.
  • To understand the rationale behind agent selection in diabetes research.

Main Methods:

  • Sub meta-analysis of randomly selected studies.
  • Review of experimental diabetes research over the last 15 years.
  • Comparative analysis of alloxan and streptozotocin in diabetogenic studies.

Main Results:

  • Despite alloxan's lower cost and greater availability, streptozotocin appears to be more frequently used.
  • An unexpected trend in agent preference was observed in recent literature.
  • The review highlights a discrepancy between economic factors and common practice.

Conclusions:

  • Further investigation into the reasons for preferring streptozotocin over alloxan is warranted.
  • Understanding agent selection is crucial for the interpretation of antidiabetic research.
  • The findings prompt a re-evaluation of alloxan's role in experimental diabetes models.
Keywords:
AlloxanAnimalsDiabetes mellitusDiabetogenic agentStreptozotocin

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