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Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?
James A Tsatsaronis1, Sandra Franch-Arroyo2, Ulrike Resch3
1Department of Regulation in Infection Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany; Current address: School of Biological Sciences, University of Wollongong, 2522 Wollongong, Australia; Both authors contributed equally to this work.
Abstract:
Both extracellular RNAs and extracellular vesicles (EVs) have recently garnered attention as novel mediators of intercellular communication in eukaryotes and prokaryotes alike. EVs not only permit export of RNA, but also facilitate delivery and trans-kingdom exchange of these and other biomolecules, for instance between microbes and their hosts. In this Opinion article, we propose that EV-mediated export of RNA represents a universal mechanism for interkingdom and intrakingdom communication that is conserved among bacterial, archaeal, and eukaryotic microbes. We speculate how microbes might use EV RNA to influence target cell gene expression or manipulate host immune responses.
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