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Ocular complications following treatment in the Postnatal Growth and Retinopathy of Prematurity (G-ROP) Study

David Morrison1, James Shaffer2, Gui-Shuang Ying2

  • 1Vanderbilt University Medical Center, Nashville Tennessee.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|March 18, 2018
PubMed

Insights

Treatment for retinopathy of prematurity (ROP) using laser or intravitreal bevacizumab (IVB) has very low complication rates. However, about 9% of laser-treated eyes experienced disease progression after ROP treatment.

Area of Science:

  • Ophthalmology
  • Neonatal Care
  • Medical Research

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of visual impairment in premature infants.
  • Effective treatment is crucial to prevent severe vision loss.

Purpose of the Study:

  • To assess the frequency of ocular complications and disease progression after ROP treatment.
  • To compare outcomes between laser therapy and intravitreal bevacizumab (IVB).

Main Methods:

  • Retrospective cohort study of 1,004 eyes treated for ROP across 29 North American NICUs.
  • Data abstracted from medical records up to 15 months post-treatment.
  • Complications and disease progression categorized by treatment modality (laser vs. IVB).

Main Results:

  • Overall complication rates were low: 2.6% for laser-treated eyes and 0% for IVB-treated eyes.
  • Disease progression occurred in 9.2% of laser-treated eyes versus 0% of IVB-treated eyes.
  • Vitreous hemorrhage occurred in 5.4% of laser-treated eyes.

Conclusions:

  • ROP treatment with laser or IVB demonstrates a low incidence of ocular complications.
  • A significant proportion of eyes treated with laser (9%) showed disease progression post-therapy.
  • IVB appears to have a favorable safety profile with no observed complications or progression in this cohort.
Abstract

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