Related Experiment Video
Updated: Feb 13, 2026
08:13
Producing Gene Deletions in Escherichia coli by P1 Transduction with Excisable Antibiotic Resistance Cassettes
Published on: September 1, 2018
18.0K
ACE insertion/deletion polymorphism is positively associated with resistant hypertension in Morocco
R Abouelfath1, R Habbal2, A Laaraj2
1Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, University Hassan II, 19 Rue Tarik Ibnou Ziad, BP. 9154 Casablanca, Morocco.
Gene
|March 18, 2018
Summary
The angiotensin-converting enzyme (ACE) gene DD genotype is linked to resistant hypertension. Physical activity also contributes to this condition, suggesting a genetic and lifestyle link.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Hypertension Research
Background:
- Resistant hypertension affects a significant portion of hypertensive patients.
- The angiotensin-converting enzyme (ACE) gene is a key component of the renin-angiotensin system, influencing blood pressure.
- Genetic variations in the ACE gene, such as I/D polymorphism, may play a role in hypertension development and severity.
Purpose of the Study:
- To investigate the association between the I/D polymorphisms of the ACE gene and resistant hypertension versus essential controlled hypertension.
- To explore the relationship between ACE gene genotypes and clinical parameters in hypertensive patients.
Main Methods:
- Genotyping of the ACE gene I/D polymorphism in patients with resistant and controlled hypertension.
- Statistical analysis to compare genotype frequencies between groups.
- Analysis of clinical parameters, including physical activity, in relation to hypertension status.
Main Results:
- The homozygous mutant DD genotype of the ACE gene was more prevalent in patients with resistant hypertension (58.1%) compared to controlled hypertension (41.9%).
- Conversely, the homozygous wild (II) genotype was more common in controlled hypertension (70.6%) than resistant hypertension (29.4%).
- The heterozygous (ID) genotype was also more frequent in controlled hypertension patients (63.6%) than resistant hypertension patients (36.4%), with a statistically significant difference (p=0.04).
- Physical activity was identified as a contributing factor to resistant hypertension (P<0.05).
Conclusions:
- The homozygous mutant DD genotype of the ACE gene is associated with resistant hypertension in the studied population.
- Physical activity is a significant clinical factor associated with resistant hypertension.
- Further research with larger sample sizes is warranted to validate these findings.
Keywords:
ACE genotypeAngiotensin-converting enzymeI/D polymorphismPolymerase chain reactionResistant hypertensionMore Related Videos
Related Concept Videos
01:05Single Nucleotide Polymorphisms-SNPs
18.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.6K
01:28Hypertension I: Introduction
957
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
957
01:29Hypertension II: Pathophysiology
1.0K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.0K
02:32Position-effect Variegation
7.1K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K
01:23Hypertension V: Nursing Management
490
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
490
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K