Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
Bone Disorders01:29

Bone Disorders

5.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.3K
Disorders of Leukocytes01:27

Disorders of Leukocytes

2.0K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.0K
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.5K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.5K
Panic Disorder01:27

Panic Disorder

810
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
810

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human germline biallelic loss-of-function <i>OSMR</i> variants cause severe allergic disease.

Journal of human immunity·2026
Same author

Human ISG15 deficiency unveils impaired healing of ulcerations via type I interferon-mediated fibrosis.

Journal of human immunity·2026
Same author

Extended clinical phenotypes and long-term outcomes of phosphoglucomutase-3 deficiency.

Journal of human immunity·2026
Same author

Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations.

Blood advances·2025
Same author

Human germline biallelic loss-of-function <i>OSMR</i> variants cause severe allergic disease.

medRxiv : the preprint server for health sciences·2025
Same author

Hereditary Alpha-Tryptasemia Is Associated With Ongoing Symptoms in Individuals With Celiac Disease Despite Following a Gluten-free Diet.

The American journal of gastroenterology·2025
Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026
Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026
Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026
Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026
Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026
Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K

Primary atopic disorders.

Jonathan J Lyons1, Joshua D Milner2

  • 1Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

The Journal of Experimental Medicine
|March 18, 2018
PubMed
Summary
This summary is machine-generated.

Studying single-gene disorders reveals key pathways in immune responses and allergic diseases. This research identifies therapeutic targets for hypersensitivity, benefiting patients with various allergic conditions.

More Related Videos

Assessment and Communication for People with Disorders of Consciousness
07:37

Assessment and Communication for People with Disorders of Consciousness

Published on: August 1, 2017

9.6K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K
Assessment and Communication for People with Disorders of Consciousness
07:37

Assessment and Communication for People with Disorders of Consciousness

Published on: August 1, 2017

9.6K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.8K

Area of Science:

  • Immunology
  • Genetics
  • Allergy Research

Background:

  • Monogenic disorders offer crucial insights into human immunity.
  • Understanding the pathogenesis of allergic diseases is critical.
  • These disorders illuminate pathways involved in atopy development.

Purpose of the Study:

  • Review single-gene disorders causing severe allergic phenotypes.
  • Identify fundamental pathways contributing to hypersensitivity.
  • Propose therapeutic strategies for allergic diseases.

Main Methods:

  • Literature review of monogenic disorders with allergic phenotypes.
  • Analysis of identified pathways in immune cell function, barrier integrity, and metabolism.
  • Discussion of therapeutic targeting of these pathways.

Main Results:

  • Several single-gene disorders are linked to severe allergic conditions.
  • These disorders highlight diverse etiological pathways, including immune cell defects, barrier dysfunction, and metabolic alterations.
  • The identified pathways are crucial for understanding atopic diathesis.

Conclusions:

  • Monogenic disorders are valuable models for studying allergic diseases.
  • Understanding these genetic underpinnings can reveal novel therapeutic targets.
  • Targeting identified pathways may offer new treatment strategies for allergic conditions.