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Predictive factors in patients eligible for pegfilgrastim prophylaxis focusing on RDI using ordered logistic

Yuko Kanbayashi1,2,3, Takeshi Ishikawa4,5, Motohiro Kanazawa4,6

  • 1Department of Pharmacy, University Hospital, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. ykokanba@koto.kpu-m.ac.jp.

Medical Oncology (Northwood, London, England)
|March 18, 2018
PubMed
Summary

Younger age, less anemia, and pegfilgrastim administered 24-72 hours post-chemotherapy help maintain relative dose intensity (RDI). This finding aids in selecting patients for pegfilgrastim prophylaxis, optimizing treatment and economics.

Keywords:
24–72 hAgeAnemiaPegfilgrastimRDI

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Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Research

Background:

  • Pegfilgrastim prophylaxis is crucial for maintaining chemotherapy's relative dose intensity (RDI) and improving patient safety.
  • Optimal patient selection for pegfilgrastim is vital for medical economics.
  • Limited information exists on factors predicting RDI maintenance with pegfilgrastim.

Purpose of the Study:

  • To identify factors predicting the maintenance of RDI in cancer patients receiving pegfilgrastim prophylaxis.
  • To inform optimal patient selection for pegfilgrastim prophylaxis from a medical economics perspective.

Main Methods:

  • Retrospective study of 166 cancer patients receiving pegfilgrastim and chemotherapy.
  • Multivariate ordered logistic regression analysis to identify factors related to RDI maintenance.
  • Receiver operating characteristic (ROC) curve analysis to determine predictive thresholds.

Main Results:

  • Younger age (OR 1.07), less severe anemia (OR 1.77), and administration of pegfilgrastim 24-72 hours post-chemotherapy (OR 0.44) significantly correlated with RDI maintenance.
  • ROC analysis identified age 70 years and above as a threshold for failing to maintain RDI (AUC: 0.74).

Conclusions:

  • Younger patients, those with less anemia, and those receiving pegfilgrastim 24-72 hours after chemotherapy are more likely to maintain RDI.
  • These factors can guide the selection of patients eligible for pegfilgrastim prophylaxis to ensure RDI maintenance.