Retroperitoneal or mesenteric primary liposarcoma: clinical and prognostic evaluations on five cases

Area of Science:

• Surgical Oncology
• Abdominal Surgery
• Rare Cancers

Background:

• Retroperitoneal or mesenteric primary liposarcoma is a rare malignant neoplasm.
• Prognosis is influenced by biological variants, surgical resection, and histological subtypes.
• This study evaluates treatment outcomes at Ivrea Hospital against high-volume center benchmarks.

Observation:

• Five patients (all male, average age 59) with acute abdomen due to liposarcoma were treated between 1982-2016.
• Histological subtypes included myxoid, well-differentiated, and dedifferentiated liposarcoma.
• All patients underwent open total tumor removal under general anesthesia.

Findings:

• All five patients achieved a healthy status post-surgery with a median follow-up of 177 months.
• Only one patient with myxoid liposarcoma experienced two recurrences.
• Successful radical resection led to favorable long-term survival.

Implications:

• Radical tumor removal, potentially involving adjacent organs, is essential for liposarcoma treatment.
• Complex cases necessitate multimodal treatment strategies in high-volume centers.
• Urgent cases require experienced abdominal surgeons to ensure outcomes comparable to specialized hub centers.