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Aortic root dilation in kidney transplant recipients
Polish Archives of Internal Medicine
|March 18, 2018
Summary
Kidney transplant recipients often experience aortic root dilation. Mammalian target of rapamycin inhibitors (mTORi) immunosuppression, unlike calcineurin inhibitors (CNIs), is linked to increased aortic root enlargement in these patients.
Area of Science:
- Nephrology
- Cardiology
- Pharmacology
Background:
- Aortic root (AoR) dilation is a risk factor for cardiovascular damage.
- Cardiovascular disease is a leading cause of mortality post-kidney transplantation (KTx).
Purpose of the Study:
- To determine the prevalence of enlarged AoR diameter in kidney transplant recipients.
- To compare AoR diameter between patients on mammalian target of rapamycin inhibitors (mTORi) and calcineurin inhibitors (CNIs).
Main Methods:
- Eighty-seven KTx recipients were analyzed, divided into mTORi and CNI groups.
- Echocardiography was used to measure AoR diameter.
- Clinical and laboratory markers of cardiovascular risk were assessed.
Main Results:
- No significant differences in baseline characteristics were observed between the mTORi and CNI groups.
- Aortic root diameter was significantly larger than calculated in the mTORi group (P=0.002), but not in the CNI group (P=0.8).
- Aortic root diameter was associated with body surface area and mTORi treatment.
Conclusions:
- Kidney transplant recipients exhibit a high prevalence of aortic root dilation.
- mTORi-based immunosuppression is associated with an increased incidence of AoR enlargement compared to CNIs.
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