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Programmable hydrogels.

Yong Wang1

  • 1Department of Biomedical Engineering, The Pennsylvania State University University Park, PA 16802, USA.

Biomaterials
|March 19, 2018
PubMed
Summary

Programmable hydrogels offer on-demand, reversible changes, unlike passive responsive hydrogels. This review covers their principles, functions, and biomedical applications in tissue engineering and drug delivery.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Hydrogels are versatile materials with tunable properties.
  • Responsive hydrogels exhibit passive or irreversible changes.
  • Programmable hydrogels offer controlled, dynamic property modulation.

Purpose of the Study:

  • To review advancements in programmable hydrogel development.
  • To categorize principles, functions, and applications.
  • To highlight their potential in biomedical fields.

Main Methods:

  • Categorization of programmable hydrogel principles (biological, chemical, physical stimulation).
  • Analysis of functional changes induced by stimuli (dimension, mechanics, cell attachment, molecular sequestration).
  • Review of biomedical applications.

Main Results:

  • Programmable hydrogels can be controlled via external stimuli.
  • Functional changes include alterations in physical and chemical properties.
  • Key applications identified in mechanobiology, tissue engineering, cell separation, and protein delivery.

Conclusions:

  • Programmable hydrogels represent a significant advancement over traditional responsive hydrogels.
  • Their controlled and dynamic nature enables sophisticated applications.
  • Further research promises expanded utility in regenerative medicine and beyond.
Keywords:
Cell separationHydrogelProtein deliveryTissue engineering

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