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Published on: December 16, 2022
Neuropsychological outcomes after pulmonary endarterectomy using moderate hypothermia and periodic circulatory arrest
Benedetta Vanini1, Valentina Grazioli2, Antonio Sciortino2
1Unit of Cardiac Surgery, Intrathoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Foundation IRCCS Policlinico San Matteo, Pavia, Italy; Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy.
Background:
In this prospective, single-center, observational study, we investigated the association between repeated short periods of circulatory arrest with moderate hypothermia during pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and different neuropsychological dimensions.
Methods:
We examined 70 patients with CTEPH, >18 to 80 years of age, who had been treated with PEA. Neuropsychological testing was performed.
Results:
Learning ability and delayed memory remained well within the normal range for patients' age. We found a statistically significant post-surgical improvement in motor speed, which was accompanied by a better quality of life and reduced symptoms of depression and anxiety.
Conclusion:
PEA with repeated short periods of circulatory arrest in CTEPH did not result in any neuropsychological complications and may even lead to post-surgical psychological improvements.
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