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Updated: Feb 13, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

707

A clinical study and meta-analysis of carotid stenosis with coexistent intracranial aneurysms

Ximeng Yang1, Jun Lu1, Junjie Wang1

  • 1Department of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|March 19, 2018
PubMed

Insights

Intracranial aneurysms (IAs) are more common in patients with carotid stenosis (CS) than previously thought. Women and individuals in Eastern countries show a higher prevalence of coexistent IAs and CS.

Area of Science:

  • Vascular Surgery
  • Neurology
  • Epidemiology

Background:

  • Carotid stenosis (CS) and intracranial aneurysms (IAs) are significant vascular conditions that can occur concurrently.
  • Understanding the prevalence of IAs in CS patients is crucial for risk stratification and management.

Purpose of the Study:

  • To determine the prevalence of intracranial aneurysms (IAs) in patients with carotid stenosis (CS).
  • To systematically review and meta-analyze existing literature on the co-occurrence of CS and IAs.

Main Methods:

  • Retrospective analysis of 577 CS patients (≥50% stenosis) diagnosed via digital subtraction angiography (DSA).
  • Systematic literature search and meta-analysis of 12 studies, including the present study, totaling 6965 CS patients.
  • Subgroup analyses were conducted based on geographical location (Asia, Europe, USA) and patient sex.

Main Results:

  • Intracranial aneurysms (IAs) were detected in 17.0% of the studied CS patients.
  • The pooled prevalence of IAs in CS patients across all studies was 6.3%.
  • Female CS patients had a 1.67 times higher risk of coexistent IAs compared to males.
  • Prevalence was significantly higher in Asian populations (10.8%) compared to European (3.0%) and US (6.0%) populations.

Conclusions:

  • The co-occurrence of carotid stenosis and intracranial aneurysms is more prevalent than previously reported.
  • Female sex and Asian ethnicity are associated with an increased risk of intracranial aneurysms in patients with carotid stenosis.

Keywords:
Carotid stenosisIntracranial aneurysmsMeta-analysisPrevalence

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