Related Experiment Video

Updated: Feb 13, 2026

Ex Vivo Infection of Live Tissue with Oncolytic Viruses
12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

13.4K

Oncolytic viruses and immunity

Shyambabu Chaurasiya1, Nanhai G Chen2, Yuman Fong3

  • 1Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

Current Opinion in Immunology
|March 19, 2018
PubMed

Insights

Oncolytic viruses (OVs) initially faced challenges, but research now shows the immune system is crucial for their anti-tumor effects. Combining OVs with immunotherapy enhances treatment outcomes.

Area of Science:

  • Immunology
  • Oncology
  • Virology

Background:

  • Early research viewed the immune system as an obstacle to oncolytic virus (OV) therapy.
  • Recent evidence highlights the immune system's critical role in OV efficacy, reversing previous assumptions.

Purpose of the Study:

  • To review the pivotal role of innate and adaptive immunity in oncolytic virotherapy.
  • To explore rational combinations of OVs with other immunotherapies for improved therapeutic outcomes.

Main Methods:

  • Literature review on the interplay between oncolytic viruses and the immune system.
  • Analysis of current research on immune responses to OVs.
  • Examination of combination strategies involving OVs and immunotherapy.

Main Results:

  • The immune system is essential, not detrimental, to the success of oncolytic virotherapy.
  • Both innate and adaptive immune responses significantly contribute to the anti-tumor effects of OVs.
  • Combining OVs with other immunotherapies shows promise for enhanced treatment efficacy.

Conclusions:

  • The immune system is a key facilitator of oncolytic virotherapy, shifting the paradigm from foe to friend.
  • Harnessing immune responses alongside OV treatment is crucial for maximizing therapeutic potential.
  • Strategic integration of OVs with immunotherapy offers a promising avenue for advancing cancer treatment.

More Related Videos

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus06:14

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

Published on: May 13, 2021

7.5K
Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

10.0K

Related Concept Videos

What are Viruses?00:50

What are Viruses?

Overview
128.4K
What is the Immune System?01:38

What is the Immune System?

Overview
132.4K
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
84.1K
Introduction to Virus01:28

Introduction to Virus

Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
1.8K
Viruses of Archaea01:29

Viruses of Archaea

Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
528
Active versus Passive Immunity01:31

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
11.0K