Related Experiment Video
Updated: Feb 13, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
11.5K
Morbillivirus Pathogenesis and Virus-Host Interactions
Kristin Pfeffermann1, Mareike Dörr1, Florian Zirkel1
1Paul-Ehrlich-Institut, Langen, Germany.
Advances in Virus Research
|March 20, 2018
Summary
Morbilliviruses, including measles virus, cause frequent outbreaks despite vaccines. This review details their history, replication, pathogenesis, and host interactions, highlighting knowledge gaps in controlling these contagious viruses.
Area of Science:
- Virology
- Immunology
- Epidemiology
Background:
- Morbilliviruses, such as measles virus, remain significant public health threats causing outbreaks globally.
- Despite effective vaccines, morbilliviruses exhibit high contagiousness and similar pathogenesis across hosts.
Purpose of the Study:
- To provide a comprehensive overview of morbillivirus history and replication.
- To recapitulate morbillivirus pathogenesis, detailing commonalities and host-specific differences.
- To summarize current knowledge on virus-host interactions, focusing on immune evasion.
Main Methods:
- Literature review of morbillivirus research.
- Synthesis of information on viral replication cycles.
- Analysis of pathogenesis and host-pathogen interactions.
Main Results:
- Morbilliviruses share conserved replication strategies and pathogenic mechanisms.
- Viral interference with innate immune responses is a key feature.
- Significant knowledge gaps persist regarding morbillivirus pathogenesis and host interactions.
Conclusions:
- Understanding morbillivirus biology is crucial for developing effective control strategies.
- Further research is needed to address knowledge gaps in viral pathogenesis and immune evasion.
- Targeting virus-host interactions may offer new therapeutic avenues.
Related Concept Videos
00:50What are Viruses?
128.4K
Overview
128.4K
01:30Pulmonary Hypertension: Classification and Pathogenesis
670
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
670
01:20Asthma: Pathogenesis and Management
1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
01:23Cystic Fibrosis: Pathogenesis
896
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
896
01:20COPD: Pathogenesis and Clinical Features
1.9K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K
02:39Predator-Prey Interactions
21.7K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.7K