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Morbillivirus Pathogenesis and Virus-Host Interactions

Kristin Pfeffermann1, Mareike Dörr1, Florian Zirkel1

  • 1Paul-Ehrlich-Institut, Langen, Germany.

Advances in Virus Research
|March 20, 2018
PubMed

Insights

Morbilliviruses, including measles virus, cause frequent outbreaks despite vaccines. This review details their history, replication, pathogenesis, and host interactions, highlighting knowledge gaps in controlling these contagious viruses.

Area of Science:

  • Virology
  • Immunology
  • Epidemiology

Background:

  • Morbilliviruses, such as measles virus, remain significant public health threats causing outbreaks globally.
  • Despite effective vaccines, morbilliviruses exhibit high contagiousness and similar pathogenesis across hosts.

Purpose of the Study:

  • To provide a comprehensive overview of morbillivirus history and replication.
  • To recapitulate morbillivirus pathogenesis, detailing commonalities and host-specific differences.
  • To summarize current knowledge on virus-host interactions, focusing on immune evasion.

Main Methods:

  • Literature review of morbillivirus research.
  • Synthesis of information on viral replication cycles.
  • Analysis of pathogenesis and host-pathogen interactions.

Main Results:

  • Morbilliviruses share conserved replication strategies and pathogenic mechanisms.
  • Viral interference with innate immune responses is a key feature.
  • Significant knowledge gaps persist regarding morbillivirus pathogenesis and host interactions.

Conclusions:

  • Understanding morbillivirus biology is crucial for developing effective control strategies.
  • Further research is needed to address knowledge gaps in viral pathogenesis and immune evasion.
  • Targeting virus-host interactions may offer new therapeutic avenues.
Keywords:
Host factorsInnate immune interferenceLife cycleMorbillivirus host rangePathogenesis

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