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Related Experiment Video

Updated: Feb 13, 2026

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Organoids for Modeling Genetic Diseases.

Maria Perez-Lanzon1, Guido Kroemer2, Maria Chiara Maiuri3

  • 1Université Paris Sud/Saclay, Faculté de Médecine, Kremlin Bicêtre, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Equipe 11, UMRS1138 INSERM, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Sorbonne Université, Paris, France.

International Review of Cell and Molecular Biology
|March 20, 2018
PubMed
Summary

Organoid systems offer a novel in vitro approach to model human diseases. These 3D organ structures are revolutionizing disease modeling, drug discovery, and regenerative medicine research.

Keywords:
3D culturesGenetic diseasesIn vitroModelingOrganoids

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Area of Science:

  • Biomedical research
  • Cell biology
  • Pathophysiology

Background:

  • Organoid systems are innovative 3D in vitro models.
  • They comprise multiple organ-specific cell types that self-organize.
  • Organoids function as miniature organs, mimicking in vivo conditions.

Purpose of the Study:

  • To review the recent applications of organoids in modeling human genetic diseases.
  • Highlighting organoids' potential in biomedical research and applications.

Main Methods:

  • Review of current literature on organoid systems.
  • Focus on organoid utilization for genetic disease modeling.

Main Results:

  • Organoids have emerged as a valid in vitro method for mimicking pathophysiology.
  • They are increasingly used in basic and translational research.
  • Applications include disease modeling, drug screening, and personalized medicine.

Conclusions:

  • Organoid technology is a rapidly advancing field with significant promise.
  • Organoid-based modeling of human genetic diseases offers valuable biomedical applications.