Pilot study to evaluate a new regimen to treat climacteric complaints with cyclic combined oestradiol...

Nineteen post-menopausal women suffering from climacteric complaints were treated with a cyclic regimen comprising 25 days on 2 mg oestradiol valerate and 5 mg medroxyprogesterone acetate daily, followed by a 5-day treatment-free interval. The mean duration of treatment was 20.2 mth. Control of bleeding was good; 9 women had slight monthly bleeding, 8 no bleeding at all, and 2 had only irregular spotting during the follow-up period. An endometrial biopsy was taken in 9 women in whom the mean duration of treatment was 30 mth. All endometrial biopsies showed an atrophic endometrium. A larger, randomized comparative study is now planned.