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Updated: Feb 13, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

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Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast

Gaochen Lan1, Jie Li2, Qiaomei Wen3

  • 1Department of Oncology, Fujian Tingzhou Hospital, Longyan, Fujian 366300, P.R. China.

Oncology Letters
|March 20, 2018
PubMed

Insights

Cytotoxic T lymphocyte associated antigen 4 (CTLA-4) expression in tumor and interstitial cells is linked to poorer outcomes in luminal B HER2-negative breast cancer. This suggests CTLA-4 blockers may benefit these patients.

Area of Science:

  • Immunology
  • Oncology
  • Pathology

Background:

  • Cytotoxic T lymphocyte associated antigen 4 (CTLA-4) is a key immune checkpoint inhibitor.
  • Its role in luminal B HER2-negative breast cancer remains under-investigated.
  • Understanding CTLA-4's function is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the expression of CTLA-4 in tumor and interstitial cells in luminal B HER2-negative breast cancer.
  • To determine the prognostic significance of CTLA-4 expression on disease-free survival (DFS).
  • To explore the potential of CTLA-4 blockade as a therapeutic strategy.

Main Methods:

  • Immunohistochemistry was used to assess tumor and interstitial CTLA-4 expression in 102 patients.
  • Statistical analysis was performed to correlate CTLA-4 expression with DFS.
  • Kaplan-Meier survival analysis was employed to compare DFS between groups.

Main Results:

  • CTLA-4 was expressed in 41.2% of tumors and 46.1% of interstitial spaces.
  • A positive association was found between tumor and interstitial CTLA-4 expression.
  • Both tumor and interstitial CTLA-4 positivity were significantly associated with shorter DFS (P<0.0001).

Conclusions:

  • Tumor and interstitial CTLA-4 expression are significant negative prognostic factors in luminal B HER2-negative breast cancer.
  • These findings support the potential utility of CTLA-4 inhibitors for this patient population.
  • Further research is warranted to validate CTLA-4 as a therapeutic target.
Keywords:
cytotoxic T lymphocyte associated antigen 4luminal B HER2-negative breast cancerprognosis

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