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Updated: Feb 13, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
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Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent

Sabine Franckenberg1, Florian Berger2, Sarah Schaerli2

  • 1Institute of Diagnostic and Interventional Radiology, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

Radiology Case Reports
|March 20, 2018
PubMed

Insights

A rare fatal anaphylactic reaction occurred in a patient receiving gadobutrol, a contrast agent for magnetic resonance imaging. This case highlights the potential for severe adverse drug reactions, even with low-prevalence agents.

Area of Science:

  • Radiology
  • Pharmacology
  • Clinical Medicine

Background:

  • Gadobutrol is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI).
  • Adverse drug reactions to gadobutrol are rare, with a prevalence of 0.32%-3.5% for any reaction and <0.1% for serious reactions.
  • Fatal anaphylactoid reactions to gadolinium-based contrast agents are exceptionally uncommon.
Keywords:
Anaphylactic reactionGadobutrolGadoliniumMRI

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