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Updated: Feb 13, 2026

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
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Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression

Weihua Li1,2, Huimin Bai2, Shiping Liu3

  • 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Wangfujing, Beijing 100730, China.

Oncotarget
|March 20, 2018
PubMed

Insights

Stearoyl-CoA desaturase 1 (SCD1) is highly expressed in endometrial cancer. Inhibiting SCD1 repressed cancer cell growth and impaired tumor progression, indicating its potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in lipid metabolism and a known target in various cancers.
  • The role of SCD1 in endometrial cancer progression remains largely unexplored.

Purpose of the Study:

  • To investigate the expression and functional significance of SCD1 in human endometrial cancer.
  • To evaluate SCD1 as a potential therapeutic target for endometrial cancer treatment.

Main Methods:

  • SCD1 expression analysis in normal endometrium, hyperplasia, and endometrial carcinoma tissues.
  • In vitro studies using short hairpin RNA (shRNA) and chemical inhibitors to knockdown SCD1 in endometrial cancer cell lines.
  • In vivo xenograft models to assess the effect of SCD1 inhibition on tumor growth.

Main Results:

  • SCD1 was highly expressed in endometrial hyperplasia and carcinoma compared to normal endometrium.
  • SCD1 knockdown significantly inhibited endometrial cancer cell proliferation and induced apoptosis.
  • Inhibition of SCD1 suppressed foci formation in a metastatic endometrial cell line and impaired tumor growth in vivo.

Conclusions:

  • SCD1 is upregulated in endometrial cancer and plays a crucial role in cancer cell growth and progression.
  • Targeting SCD1 represents a promising therapeutic strategy for endometrial cancer by disrupting lipid metabolism.
Keywords:
cell deathcell growthendometrial cancerstearoyl-CoA desaturasetherapeutic target

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