Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Microsoft Excel: Median, Quartile range, and Box Plots01:29

Microsoft Excel: Median, Quartile range, and Box Plots

3.4K
In Microsoft Excel, calculating the median, interquartile range, and creating box plots can help understand the distribution of your data.
Median and Quartile Range: The median is calculated using the formula `=MEDIAN(range)', which provides the middle value of your data set. Quartiles divide your data into four equal parts. To find the first and third quartiles, use ‘=QUARTILE(range, 1)' and ‘=QUARTILE(range, 3)', respectively. The interquartile range (IQR), which...
3.4K
Electron Transport Chains01:28

Electron Transport Chains

113.1K
The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...
113.1K
Polytene Chromosomes02:04

Polytene Chromosomes

11.0K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
11.0K
The Nucleolus02:55

The Nucleolus

10.4K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Pharmacokinetics of the Marine-Derived PDE4 Inhibitor LY104 and Its Major Metabolite M1 in Rats: A Validated LC-MS/MS Method with Sex Comparison, Multiple-Dose, Protein Binding, Metabolic Stability, and Excretion Studies.

Marine drugs·2026
Same author

Vagus nerve as the hub in peripheral immune-inflammatory response: implications for related therapeutic drugs.

Molecular biology reports·2026
Same author

Dicaffeoylquinic acid alleviates alcoholic liver disease by targeting PLA2G4B and inhibiting the MAPK signaling pathway.

Frontiers in pharmacology·2026
Same author

Licochalcone B alleviates pulmonary vascular remodeling via inhibiting Furin/TGF-β1 in pulmonary hypertension.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Structure-guided discovery of phenyl-carbamates as novel dual TRPV1 antagonists/FAAH inhibitors.

Bioorganic chemistry·2026
Same author

Baicalein alleviates anxiety symptom in Parkinson's disease by targeting Sema3A-mediated parvalbumin interneuron dysfunction.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same journal

Retraction: Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression.

Oncotarget·2026
Same journal

TRAIL-R2 in the shadows: Epigenetic silencing and clinical implications in breast cancer.

Oncotarget·2026
Same journal

Retraction: MALAT1 predicts poor survival in osteosarcoma patients and promotes cell metastasis through associating with EZH2.

Oncotarget·2026
Same journal

Laryngeal leiomyosarcoma: A rare case report and literature review.

Oncotarget·2026
Same journal

Correction: Postsurgery fluids promote transition of cancer stem cell toendothelial and AKT/mTOR activity contributing to relapse of giant cell tumors of bone.

Oncotarget·2026
Same journal

DHHC3 interferes with antitumor immunity in melanoma cells.

Oncotarget·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

12.4K

Research progress on the forkhead box C1.

Jinhua Wang1,2, Wan Li2, Xiangjin Zheng2

  • 1The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China.

Oncotarget
|March 20, 2018
PubMed
Summary
This summary is machine-generated.

The Forkhead box C1 (FOXC1) protein promotes cancer progression, metastasis, and drug resistance in various cancers. Understanding FOXC1

Keywords:
FOX familyFOXC1cancerdrug resistancestem cell

More Related Videos

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

22.8K
Design and Optimization Strategies of a High-Performance Vented Box
14:23

Design and Optimization Strategies of a High-Performance Vented Box

Published on: June 9, 2023

1.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

12.4K
Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

22.8K
Design and Optimization Strategies of a High-Performance Vented Box
14:23

Design and Optimization Strategies of a High-Performance Vented Box

Published on: June 9, 2023

1.6K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The Forkhead box C1 (FOXC1) protein is a key regulator in cellular processes like proliferation, differentiation, and apoptosis.
  • FOXC1 plays a significant role in the biological functions of various cell types.

Purpose of the Study:

  • To investigate the specific roles and underlying mechanisms of FOXC1 in the development and progression of different types of cancer.
  • To explore the association of FOXC1 with cancer drug resistance and metastasis.

Main Methods:

  • Literature review and analysis of existing studies on FOXC1 in cancer.
  • Examination of molecular pathways regulated by FOXC1, including gene expression analysis.

Main Results:

  • FOXC1 promotes the progression of multiple cancers, including breast, liver, and gastric cancers.
  • FOXC1 enhances cancer metastasis by upregulating MMP7, NEDD9, and Snail.
  • FOXC1 is implicated in cancer proliferation, invasion, and development by mediating key signaling pathways and transcription factors.

Conclusions:

  • FOXC1 is a crucial oncogene that drives cancer progression, metastasis, and drug resistance through diverse molecular mechanisms.
  • FOXC1's involvement in stem cell niche regulation suggests a role in cancer stem cell biology.
  • FOXC1 represents a potential biomarker for various diseases, particularly cancers.