Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pneumothorax-I

Pneumothorax-I

A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.

Pneumothorax-II

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Machine Learning Assessment of Pathologic Response in Lung Cancer Resections After Neoadjuvant Therapy-IASLC MPR Project.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2026

Same author

Nutritional and prognostic effects of thoracic duct obliteration during esophagectomy.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026

Same author

Resolving the Staging Dilemma in Multiple Lung Cancers: A Prevalence-Weighted Bioinformatic Approach to the 2024 IASLC Recommendations.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2026

Same author

The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies.

Nature·2025

Same author

Tumor Cell Invasion of the External Elastic Lamina Designates Visceral Pleural Invasion and Predicts Poorer Patient Outcomes in Pulmonary Nonmucinous Invasive Adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2025

Same author

Real-world application of targeted next-generation sequencing for identifying molecular variants in Asian non-small-cell lung cancer.

BMC cancer·2025

Search research articles

Related Experiment Video

Updated: Feb 13, 2026

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

Pleuroparenchymal fibroelastosis presenting with pneumothorax.

Yen-Yu Lin¹, Wen-Hu Hsu², Mei-Han Wu³

¹Division of Molecular Pathology, Pathology and Laboratory Medicine Department, Taipei Veterans General Hospital, Taipei, Taiwan.

SAGE Open Medical Case Reports

|March 20, 2018

Summary

This study describes pleuroparenchymal fibroelastosis, a rare interstitial lung disease characterized by pleural and subpleural fibrosis. Early diagnosis and understanding of this progressive condition are crucial for patient management.

Keywords:

Interstitial lung disease pleura pneumothorax

More Related Videos

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Feb 13, 2026

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

Area of Science:

Pulmonology
Pathology
Radiology

Background:

Interstitial lung diseases (ILDs) encompass a heterogeneous group of disorders affecting the lung parenchyma.
Pleuroparenchymal fibroelastosis (PPFE) is a rare form of ILD with distinct pathological and clinical features.

Observation:

A 47-year-old woman presented with spontaneous pneumothorax and bilateral lung opacities.
Imaging revealed consolidations and reticular opacities predominantly in pleural and subpleural regions.
Histopathology confirmed significant fibrosis of the visceral pleura and subpleural areas, particularly in the upper lobes.

Findings:

The case presented is consistent with pleuroparenchymal fibroelastosis, distinguished by pleural involvement and upper lobe predominance.
Pathological findings included alveolar septal elastosis and intra-alveolar fibrosis.
PPFE differs from usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP) due to its specific pleural and upper lobe characteristics and limited inflammation.

Implications:

Pleuroparenchymal fibroelastosis is a distinct interstitial lung disease with a progressive course, impacting approximately half of patients within 10 years.
Currently, no curative treatments are available for PPFE.
Accurate diagnosis through integrated clinical, imaging, and pathological assessment is vital for managing this rare lung condition.